Taurine 11 pp 1001-1014 | Cite as

Anti-inflammatory Effects of Batillaria multiformis Water Extracts via NF-кB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Cells

  • Woen-Bin Shin
  • Xin Dong
  • Yon-Suk Kim
  • Jin-Su Park
  • Su-Jin Kim
  • Eun-Ae Go
  • Eun-Kyung Kim
  • Pyo-Jam ParkEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


Batillaria multiformis (B. multiformis) belong to gastropods. They live generally in the sandpit of the lagoons and the estuaries of the intertidal zone. Most of them are distributed in Korea, Japan and China. In this study, we investigated the anti-inflammatory potential of B. multiformis water extracts (BMW). The results showed that the extracts significantly decreased the production of nitric oxide (NO) and pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in LPS-induced RAW 264.7 macrophages. In addition, the extracts suppressed the protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose dependent manner. Further investigation indicated that BMW suppressed phosphorylated c-Jun N-terminal kinase (JNK), extracellular regulated protein kinase (ERK) and p38 through the MAPK signaling pathway and influenced the NF-κB signaling pathway by suppressing the IκBα degradation in LPS-induced RAW 264.7 macrophages.


Taurine Batillaria multiformis RAW 264.7 cells Anti-inflammation 



This chapter was modified from the paper published by our group in Food Science and Biotechnology (Kim et al. 2017; 26(6):1633–1640). The related contents are re-used with the permission.

Conflict of Interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Woen-Bin Shin
    • 1
  • Xin Dong
    • 1
  • Yon-Suk Kim
    • 2
  • Jin-Su Park
    • 1
  • Su-Jin Kim
    • 1
  • Eun-Ae Go
    • 1
  • Eun-Kyung Kim
    • 3
  • Pyo-Jam Park
    • 1
    • 4
    Email author
  1. 1.Department of Applied Life ScienceKonkuk UniversityChungjuRepublic of Korea
  2. 2.BK21plus Glocal Education Program of Nutraceuticals DevelopmentKonkuk UniversityChungjuRepublic of Korea
  3. 3.Division of Food Bio ScienceKonkuk UniversityChungjuRepublic of Korea
  4. 4.Department of Integrated BiosciencesKonkuk UniversityChungjuRepublic of Korea

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