Advertisement

Taurine 11 pp 1001-1014 | Cite as

Anti-inflammatory Effects of Batillaria multiformis Water Extracts via NF-кB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Cells

  • Woen-Bin Shin
  • Xin Dong
  • Yon-Suk Kim
  • Jin-Su Park
  • Su-Jin Kim
  • Eun-Ae Go
  • Eun-Kyung Kim
  • Pyo-Jam ParkEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Batillaria multiformis (B. multiformis) belong to gastropods. They live generally in the sandpit of the lagoons and the estuaries of the intertidal zone. Most of them are distributed in Korea, Japan and China. In this study, we investigated the anti-inflammatory potential of B. multiformis water extracts (BMW). The results showed that the extracts significantly decreased the production of nitric oxide (NO) and pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in LPS-induced RAW 264.7 macrophages. In addition, the extracts suppressed the protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose dependent manner. Further investigation indicated that BMW suppressed phosphorylated c-Jun N-terminal kinase (JNK), extracellular regulated protein kinase (ERK) and p38 through the MAPK signaling pathway and influenced the NF-κB signaling pathway by suppressing the IκBα degradation in LPS-induced RAW 264.7 macrophages.

Keywords

Taurine Batillaria multiformis RAW 264.7 cells Anti-inflammation 

Notes

Acknowledgement

This chapter was modified from the paper published by our group in Food Science and Biotechnology (Kim et al. 2017; 26(6):1633–1640). The related contents are re-used with the permission.

Conflict of Interest

The authors declare that there are no conflicts of interest.

References

  1. Ahmad N, Chen LC, Gordon MA, Laskin JD, Laskin DL (2002) Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia. J Leukoc Biol 71:1005–1011PubMedGoogle Scholar
  2. An S, Koh C (1992) Environments and distribution of benthic animals on the mangyung-Dongjin tidal flat, west coast of Korea. J Oceanol Soc Korea 27:78–90Google Scholar
  3. Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649–683CrossRefGoogle Scholar
  4. Bhat NR, Zhang P, Lee JC, Hogan EL (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18:1633–1641CrossRefGoogle Scholar
  5. Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D, Maniatis T (1995) Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev 9(13):1586–1597CrossRefGoogle Scholar
  6. Chen WQ, Jin H, Nguyen M, Carr J, Lee YJ, Hsu CC, Faiman MD, JV S, Wu JY (2001) Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons. J Neurosci Res 66:612–619CrossRefGoogle Scholar
  7. Conese M, Assael BM (2001) Bacterial infections and inflammation in lungs of cystic fibrosis patients. Infect Dis J 20:207–213CrossRefGoogle Scholar
  8. Coskun M, Olsen J, Seidelin JB, Nielsen OH (2011) MAP kinases in inflammatory bowel disease. Clin Chim Acta 412:513–520CrossRefGoogle Scholar
  9. Dong C, Davis RJ, Flavell RA (2002) MAP kinases in the immune response. Annu Rev Immunol 20:55–72CrossRefGoogle Scholar
  10. Fang L, Wu HM, Ding PS, Liu RY (2014) TLR2 mediates phagocytosis and autophagy through JNK signaling pathway in staphylococcus aureus-stimulated RAW 264.7 cells. Cell Signal 26:806–814CrossRefGoogle Scholar
  11. Gloire G, Legrand-Poels S, Piette J (2006) NF-kappa B activation by reac tive oxygen species: fifteen years later. Biochem Pharmacol 72:1493–1505CrossRefGoogle Scholar
  12. Godfrey DA, Farms WB, Godfrey TG, Mikesell NL, Liu J (2000) Amino acid concentrations in rat cochlear nucleus and superior olive. Hear Res 150:189–205CrossRefGoogle Scholar
  13. Hanna J, Chahine R, Aftimos G, Nader M, Mounayar A, Esseily F, Chamat S (2004) Protective effect of taurine against free radicals damage in the rat myocardium. Exp Toxicol Path 56:189–194CrossRefGoogle Scholar
  14. Karin M, Gallagher E (2002) From JNK to pay dirt: Jun kinases, their bio chemistry, physiology and clinical importance. IUBMB Life 57:283–295CrossRefGoogle Scholar
  15. Kibayashi E, Yokogoshi H, Mizue H, Miura K, Yoshita K, Nakagawa H, Naruse Y, Sokejima S, Kagamimori S (2000) Daily dietary taurine intake in Japan. Adv Exp Med Biol 483:137–142CrossRefGoogle Scholar
  16. Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP (1999) Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol 58:759–765CrossRefGoogle Scholar
  17. Kim YS, Kim EK, Amila Srilal Nawarathna WP, Dong X, Shin WB, Park JS, Moon SH, Park PJ (2007) Immune-stimulatory effects of Althaea rosea flower extracts through the MAPK signaling pathway in RAW264.7 cells. Molecules 22:679CrossRefGoogle Scholar
  18. Kim YS, Shin WB, Dong X, Kim EK, Amila Srilal Nawarathna WP, Kim HJ, Park PJ (2017) Anti-inflammatory effect of the extract from fermented Asterina pectinifera with Cordyceps militaris mycelia in LPS-induced RAW 264.7 macrophages. Food Sci Biotechnol 22:1633CrossRefGoogle Scholar
  19. Lee JS, Choi JW, Sohng JK, Pandey R, Park YI (2016) The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway. Int Immunopharmacol 31:88–97CrossRefGoogle Scholar
  20. Murakami A, Ohigashi H (2007) Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int J Cancer 121:2357–2363CrossRefGoogle Scholar
  21. Oktawia PW, Karen LK, Anne ZJ, Max C, Yu C (2010) The potential protective effects of taurine on coronary heart disease. Atherosclerosis 208:19–25CrossRefGoogle Scholar
  22. Phelps CB, Sengchanthalangsy LL, Huxford T, Ghosh G (2000) Mechanism of mechanism of IκBα binding to NF-κB dimers. J Biol Chem 275(38):29840–29846CrossRefGoogle Scholar
  23. Sochor J, Nejdl L, Ruttkay-Nedecky B, Bezdekova A, Lukesova K, Zitka O, Cernei N, Mares P, Pohanka M, Adama V, Babula P, Beklova M, Zeman L, Kizek R (2014) Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach. J Appl Biomed 12:97–110CrossRefGoogle Scholar
  24. Tak PP, Firestein GS (2001) NF-ĸB: a key role in inflammatory diseases. J Clin Invest 107(1):7–11CrossRefGoogle Scholar
  25. Youn HS, Lim HJ, Choi YJ, Lee YJ, Lee JY, Ryu JH (2008) Selenium sup presses the activation of transcription factor NF-κB and IRF3 induced by TLR3 or TLR4 agonists. Int Immunopharmacol 8:495–501CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Woen-Bin Shin
    • 1
  • Xin Dong
    • 1
  • Yon-Suk Kim
    • 2
  • Jin-Su Park
    • 1
  • Su-Jin Kim
    • 1
  • Eun-Ae Go
    • 1
  • Eun-Kyung Kim
    • 3
  • Pyo-Jam Park
    • 1
    • 4
    Email author
  1. 1.Department of Applied Life ScienceKonkuk UniversityChungjuRepublic of Korea
  2. 2.BK21plus Glocal Education Program of Nutraceuticals DevelopmentKonkuk UniversityChungjuRepublic of Korea
  3. 3.Division of Food Bio ScienceKonkuk UniversityChungjuRepublic of Korea
  4. 4.Department of Integrated BiosciencesKonkuk UniversityChungjuRepublic of Korea

Personalised recommendations