Taurine 11 pp 857-867 | Cite as

Glucose-Taurine Reduced Exerts Neuroinflammatory Responses by Inhibition of NF-κB Activation in LPS-Induced BV2 Microglia

  • Hwan Lee
  • Dong-Sung Lee
  • Kyung Ja Chang
  • Sung Hoon Kim
  • Sun Hee Cheong
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


We want to find the anti-neuroinflammatory action of the taurine derivative Glucose-Taurine Reduced (G-T-R). The anti-neuroinflammatory action by G-T-R were investigated in lipopolysaccharide (LPS)-induced BV2 microglia. G-T-R inhibited the production of nitric oxide and prostaglandin E2, and down-regulated the protein expression of inducible NO synthase and cyclooxygenase-2. In addition, G-T-R reduced the cytokines secretion such as tumor necrosis factor (TNF-α), interleukin (IL) -1β and IL-6, in BV2 microglia treated with LPS. In addition, G-T-R dose-dependently decreased the activation of nuclear factor-kappa B. These findings confirmed the anti-neuroinflammatory activity of G-T-R, which may exert protective effects against neuroinflammatory-related diseases.


Glucose-taurine reduced (G-T-R) BV2 microglia Anti-neuroinflammatory effects 



nuclear factor-kappa B


bicinchoninic acid


central nervous system






enhanced chemiluminescence


ethylene glycol tetra-acetic acid


fetal bovine serum


glucose-taurine reduced


horseradish peroxidase




inducible nitric oxide synthase




3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide


nitric oxide


phosphate buffered saline


prostaglandin E2


reactive oxygen species


tumor necrosis factor–alpha


alpha-minimum essential medium



This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2015R1C1A1A02036465 & NRF-2018R1C1B6001913).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Hwan Lee
    • 1
  • Dong-Sung Lee
    • 1
  • Kyung Ja Chang
    • 2
  • Sung Hoon Kim
    • 3
  • Sun Hee Cheong
    • 4
  1. 1.College of PharmacyChosun UniversityDong-gu, GwangjuRepublic of Korea
  2. 2.Department of Food and NutritionInha UniversityIncheonRepublic of Korea
  3. 3.Department of ChemistryKonkuk UniversitySeoulRepublic of Korea
  4. 4.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuRepublic of Korea

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