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Taurine 11 pp 691-703 | Cite as

Hepatoprotective Activity of a Taurine-Rich Water Soluble Extract from Octopus vulgaris Meat

  • WonWoo Lee
  • Eui Jeong Han
  • Eunyeong Park
  • Eun-Ji Shin
  • Hee-Jin Han
  • Kyungsook Jung
  • Soo-Jin Heo
  • Eun-A Kim
  • Kil-Nam Kim
  • Ihn-Sil Kwak
  • Min Ju Kim
  • Ginnae AhnEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

In this study, we investigated the hepatoprotective activity of the water extract derived from Octopus vulgaris meat (OM). First of all, a water extract prepared from OM (OMW) showed the high extraction yield (48.22%) and the highest taurine content (39.84%) in free amino acids. OMW exhibited the high value of reducing power, ABTS and hydrogen peroxide radical scavenging activities in dose-dependent manner. The taurine-rich OMW also led to the reduced intracellular reactive oxygen species (ROS) generation with the increased cell survival in H2O2-treated Chang liver cells. In addition, OMW decreased the apoptotic phenomenon, including the formations of apoptotic bodies and sub-G1 DNA contents by regulating the protein expressions of apoptosis-related molecules such as Bcl-2 and Bax. From these results, this study indicated the taurine-rich OMW protected hepatocytes against oxidative stress. These findings suggest that OWM may be a novel potential antioxidant resource.

Keywords

Taurine Octopus vulgaris Hepatoprotective activity Apoptosis 

Notes

Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1A6A1A03024314).

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • WonWoo Lee
    • 1
  • Eui Jeong Han
    • 2
  • Eunyeong Park
    • 3
  • Eun-Ji Shin
    • 2
  • Hee-Jin Han
    • 2
  • Kyungsook Jung
    • 4
  • Soo-Jin Heo
    • 5
  • Eun-A Kim
    • 5
  • Kil-Nam Kim
    • 6
  • Ihn-Sil Kwak
    • 7
  • Min Ju Kim
    • 2
  • Ginnae Ahn
    • 2
    • 3
    Email author
  1. 1.Freshwater Biosources Utilization Bureau, Bioresources Industrialization Support DivisionNakdonggang National Institute of Biological Resources (NNIBR)SangjuRepublic of Korea
  2. 2.Department of Food Technology and NutritionChonnam National UniversityYeosuRepublic of Korea
  3. 3.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuRepublic of Korea
  4. 4.Natural Product Material Research CenterKorea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea
  5. 5.Jeju International Marine Science Center for Research & EducationKorea Institute of Ocean Science & Technology (KIOST)JejuRepublic of Korea
  6. 6.Chuncheon CenterKorea Basic Science Institute (KBSI)ChuncheonRepublic of Korea
  7. 7.Faculty of Marine TechnologyChonnam National UniversityYeosuRepublic of Korea

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