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Taurine 11 pp 45-59 | Cite as

Inhibition of Renin-Angiotensin System from Conception to Young Mature Life Induces Salt-Sensitive Hypertension via Angiotensin II-Induced Sympathetic Overactivity in Adult Male Rats

  • Tippaporn Bualeong
  • James Michael Wyss
  • Sanya RoysommutiEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Previous studies indicate that perinatal compromise of taurine causes cardiovascular disorders in adults via the influence of taurine on renin-angiotensin system (RAS). This study tested whether perinatal inhibition of the RAS would itself alter the adult cardiovascular system in a similar way. Female Sprague-Dawley rats were fed normal rat chow and given water alone (Control) or water containing captopril (400 mg/l) from conception until weaning. Then, the male offspring drank water or water containing captopril until 5 weeks of age followed by normal rat chow and water alone until 7 weeks of age. Thereafter, they drank water alone (Control, Captopril) or 1% NaCl solution (Control+1%, Captopril+1%). At 9 weeks of age, all animals were implanted with femoral arterial and venous catheters. Forty-eight hours later, blood chemistry, glucose tolerance, and hemodynamic parameters were determined in freely moving conscious rats. Then, the same experiments were repeated 2 days after captopril treatment. Body weights, kidney and heart to body weight ratios, fasting and non-fasting blood sugar, glucose tolerance, and heart rates were not significantly different among groups. Further, plasma sodium, mean arterial pressure, and sympathetic activity significantly increased whereas baroreflex sensitivity decreased in Captopril+1% compared to other groups. These changes were normalized by acute captopril treatment and the arterial pressure differences also by acute ganglionic and central adrenergic blockade. The present study suggests that inhibition of the RAS in the early life induces RAS overactivity, leading to salt-sensitive hypertension via sympathetic nervous system overactivity and depressed baroreflex sensitivity in adult male rats.

Keywords

Baroreflex Captopril Hypertension Renin-angiotensin system Salt sensitivity Sympathetic activity 

Abbreviations

ACE

angiotensin-converting enzyme

AT1 receptor

angiotensin II subtype 1 receptor

AT2 receptor

angiotensin II subtype 2 receptor

Captopril+1%

captopril-treated rat with 1% NaCl

Control+1%

control rat with 1% NaCl

mRNA

messenger ribonucleic acid

RAS

renin-angiotensin system

SHR

spontaneously hypertensive rat

WKY

Wistar-Kyoto

Notes

Acknowledgements

This study was supported by Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Tippaporn Bualeong
    • 1
    • 2
  • James Michael Wyss
    • 3
  • Sanya Roysommuti
    • 1
    Email author
  1. 1.Department of Physiology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand
  2. 2.Department of Physiology, Faculty of Medical ScienceNaresuan UniversityPhitsanulokThailand
  3. 3.Department of Cell, Developmental and Integrative Biology, School of MedicineUniversity of Alabama at BirminghamBirminghamUSA

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