Taurine 11 pp 507-520 | Cite as

Taurine Increases Spermatozoa Quality and Function in Asthenospermia Rats Impaired by Ornidazole

  • Yanting Du
  • Hong Liu
  • Meng Zhang
  • Shu Zhang
  • Jianmin Hu
  • Gaofeng Wu
  • Jiancheng Yang
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


Asthenospermia has been considered as one of the crucial causes of male infertility, which was closely related to epididymal dysfunction. Lots of documents have revealed that taurine palys an important role in male reproduction, including antioxidation, membrane stabilization, stimulation of sexual hormone secretion and elevation of sperm quality. The objective of this study was to expose the effect of taurine on spermatozoa quality and function in ornidazole-induced asthenospermia rats. We found that taurine treatment could obviously recover the decline of cauda epididymal sperm count, viability and motility, and the elevation of sperm abnormality in asthenospermia animals. Spermatozoa acrosin, LDH-X, SDH and CCO activities of model rats also were notably increased by taurine administration. The present data indicated that taurine could raise spermatozoa quality and function by elevating mitochondrial energy metabolism. Notably, taurine supplementation markedly raised serum GnRH, LH and T levels in asthenospermia rays, suggesting taurine rescued asthenosperm by means of stimulating hypothalamic-pituitary-testicular axis secretion. We also found that concentrations of asthenospermia epididymal carnitine, SA, α-Glu and ACP, and mRNA expression levels of MMP7 and IDO2 were significantly rised by taurine administration, indicating taurine may protect epididymal epithelium structure, improve secretion activity, and maintain intraluminal microenvironment homeostasis. Finally, the present results showed taurine effectively increased cauda epididymal SOD, GSH and γ-GT levels in model rats, reduced ROS and MDA production, suggesting epididymal antioxidant ability of asthenospermia rats could be elevated by taurine treatment. To sum up, our results indicated that taurine can promote spermatozoa quality and function in ornidazole-induced asthenospermia rats by facilitating epididymal epithelium secretion and luminal microenvironment homeostasis.


Taurine Spermatozoa quality and function Sexual hormone Epididymal function Ornidazole-induced asthenospermia rats 



acid phosphatase


cytochrome c oxidase


follicle-stimulating hormone


gonadotropin-releasing hormone


reduced glutathione hormone


indoleamine 2, 3-dioxygenase


lactate dehydrogenase X


luteinizing hormone




matrix metalloproteinase 7


reactive oxygen species


sialic acid


sorbitol dehydrogenase


superoxide dismutase









This work was supported by the National Natural Science Foundation of China (No.31272522) and Program for Liaoning Excellent Talents in University (No. LJQ2014073).

Author Contributions

JY and JH conceived the study and participated in its design and coordination and helped to draft the manuscript. TM performed the sexual function tests, participated in the study design and drafted the manuscript. SL and GW performed the hormone study. QY and YZ participated in the detection of NOS/NO and performed the statistical analysis. All authors read and approved the final manuscript.

Conflict of Interest

All authors declare no conflicts of interest, financial or otherwise.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Yanting Du
    • 1
  • Hong Liu
    • 2
  • Meng Zhang
    • 1
  • Shu Zhang
    • 1
  • Jianmin Hu
    • 1
  • Gaofeng Wu
    • 1
  • Jiancheng Yang
    • 1
  1. 1.Liaoning Provincial Key Laboratory of ZoonosisCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural UniversityShenyangChina
  2. 2.Experimental Animal CenterLiaoning University of Traditional Chinese MedicineShenyangChina

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