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Taurine 11 pp 507-520 | Cite as

Taurine Increases Spermatozoa Quality and Function in Asthenospermia Rats Impaired by Ornidazole

  • Yanting Du
  • Hong Liu
  • Meng Zhang
  • Shu Zhang
  • Jianmin Hu
  • Gaofeng Wu
  • Jiancheng Yang
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Asthenospermia has been considered as one of the crucial causes of male infertility, which was closely related to epididymal dysfunction. Lots of documents have revealed that taurine palys an important role in male reproduction, including antioxidation, membrane stabilization, stimulation of sexual hormone secretion and elevation of sperm quality. The objective of this study was to expose the effect of taurine on spermatozoa quality and function in ornidazole-induced asthenospermia rats. We found that taurine treatment could obviously recover the decline of cauda epididymal sperm count, viability and motility, and the elevation of sperm abnormality in asthenospermia animals. Spermatozoa acrosin, LDH-X, SDH and CCO activities of model rats also were notably increased by taurine administration. The present data indicated that taurine could raise spermatozoa quality and function by elevating mitochondrial energy metabolism. Notably, taurine supplementation markedly raised serum GnRH, LH and T levels in asthenospermia rays, suggesting taurine rescued asthenosperm by means of stimulating hypothalamic-pituitary-testicular axis secretion. We also found that concentrations of asthenospermia epididymal carnitine, SA, α-Glu and ACP, and mRNA expression levels of MMP7 and IDO2 were significantly rised by taurine administration, indicating taurine may protect epididymal epithelium structure, improve secretion activity, and maintain intraluminal microenvironment homeostasis. Finally, the present results showed taurine effectively increased cauda epididymal SOD, GSH and γ-GT levels in model rats, reduced ROS and MDA production, suggesting epididymal antioxidant ability of asthenospermia rats could be elevated by taurine treatment. To sum up, our results indicated that taurine can promote spermatozoa quality and function in ornidazole-induced asthenospermia rats by facilitating epididymal epithelium secretion and luminal microenvironment homeostasis.

Keywords

Taurine Spermatozoa quality and function Sexual hormone Epididymal function Ornidazole-induced asthenospermia rats 

Abbreviations

ACP

acid phosphatase

CCO

cytochrome c oxidase

FSH

follicle-stimulating hormone

GnRH

gonadotropin-releasing hormone

GSH

reduced glutathione hormone

IDO2

indoleamine 2, 3-dioxygenase

LDH-X

lactate dehydrogenase X

LH

luteinizing hormone

MDA

malondialdehyde

MMP7

matrix metalloproteinase 7

ROS

reactive oxygen species

SA

sialic acid

SDH

sorbitol dehydrogenase

SOD

superoxide dismutase

T

testosterone

α-Glu

α-glucosidase

γ-GT

γ-glutamyl-transferase

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No.31272522) and Program for Liaoning Excellent Talents in University (No. LJQ2014073).

Author Contributions

JY and JH conceived the study and participated in its design and coordination and helped to draft the manuscript. TM performed the sexual function tests, participated in the study design and drafted the manuscript. SL and GW performed the hormone study. QY and YZ participated in the detection of NOS/NO and performed the statistical analysis. All authors read and approved the final manuscript.

Conflict of Interest

All authors declare no conflicts of interest, financial or otherwise.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Yanting Du
    • 1
  • Hong Liu
    • 2
  • Meng Zhang
    • 1
  • Shu Zhang
    • 1
  • Jianmin Hu
    • 1
  • Gaofeng Wu
    • 1
  • Jiancheng Yang
    • 1
  1. 1.Liaoning Provincial Key Laboratory of ZoonosisCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural UniversityShenyangChina
  2. 2.Experimental Animal CenterLiaoning University of Traditional Chinese MedicineShenyangChina

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