The Potential Effects of Taurine in Mitigation of Radiation Nephropathy
Taurine (2-aminoethanesulfonic acid) is a sulfur-containing organic acid possessing several important effects, including antioxidant and anti-inflammatory ones. Exposure to ionizing radiation generates free radicals and reactive oxygen species (ROS) in irradiated cells, and free radical generation leads to oxidative stress. It is known that radiation nephropathy includes an inflammation-based process in which ROS and cytokines are responsible. Different doses of explored radiation can cause apoptosis, inflammation and a profound oxidative stress in kidneys. Oxidative stress is involved in renal injury after exposure to both ionizing radiation and inflammation. In this review, we describe the protective effect of taurine against several kidney diseases and the potential effects of taurine in the mitigation of radiation nephropathy. We also report that X-irradiation decreased the expression of taurine and TauT in the kidney. Taurine administration suppressed the decrease in the expression of taurine and TauT in the kidney after radiation exposure. Taurine might contribute to the mitigation of kidney injury induced by radiation.
KeywordsKidney Radiation Mitigation Taurine transporter Reactive oxygen species (ROS)
reactive oxygen species
We thank Yui Naganuma, Yusuke Hasegawa and Riki Miyabayashi for the handling of the animals and for assistance in the drug administration part of this work. This work was supported by JSPS KAKENHI Grant Number JP 17 K15809 and JP 17H04654.
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