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Taurine 11 pp 463-470 | Cite as

Taurine Supplementation Ameliorates Arsenic-Induced Hepatotoxicity and Oxidative Stress in Mouse

  • Shuangxing Li
  • Bin Kai Wei
  • Jinhua Wang
  • Guangtao Dong
  • Xiujie Wang
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

We previously reported that taurine treatment inhibited arsenic (As)-induced apoptosis in the liver of mice. This study was designed to explore the effect of taurine on liver function and its underlying mechanism in As-exposed mice. Mice were randomly divided into 3 groups, ten mice in each group. Group 1, control group, only orally received drinking water alone. Group 2, As intoxication group, was exposed to 4 mg/L As2O3 via drinking water for 60 days. Group 3, taurine protection group, was treated with 4 mg/L As2O3 and 150 mg/kg both. Taurine administration significantly revered the increases of alanine transaminase (ALT) and aspartate transaminase (AST) activities in serum. The decrease of glutathione (GSH) was inhibited with taurine treatment in the liver of As-exposed mice. At the same time, taurine significantly inhihibited As-induced enhancement of malondialdehyde (MDA) in the liver. Here we show that taurine protective effect on liver function in As-exposed mice maybe involve lipid peroxidation.

Keywords

Taurine Arsenic Hepatoxicity Oxidative stress 

Abbreviations

ALT

alanine transaminase

As

arsenic

AST

aspartate transaminase

GSH

glutathione

MDA

malondialdehyde

References

  1. Anwar-Mohamed A, Abdelhamid G, Amara IE, El-Kadi AO (2012) Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL/6 mice. Arch Toxicol 86:897–910CrossRefGoogle Scholar
  2. Ayala-Fierro F, Barber DS, Rael LT, Carter DE (1999) In vitro tissue specificity for arsine and arsenite toxicity in the rat. Toxicol Sci 52:122–129CrossRefGoogle Scholar
  3. Bardach AE, Ciapponi A, Soto N, Chaparro MR, Calderon M, Briatore A, Cadoppi N, Tassara R, Litter MI (2015) Epidemiology of chronic disease related to arsenic in Argentina: a systematic review. Sci Total Environ 538:802–816CrossRefGoogle Scholar
  4. Batista TM, Ribeiro RA, da Silva PM, Camargo RL, Lollo PC, Boschero AC, Carneiro EM (2013) Taurine supplementation improves liver glucose control in normal protein and malnourished mice fed a high-fat diet. Mol Nutr Food Res 57:423–434CrossRefGoogle Scholar
  5. Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP (2005) Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol 206:288–298CrossRefGoogle Scholar
  6. Bosgelmez II, Soylemezoglu T, Guvendik G (2008) The protective and antidotal effects of taurine on hexavalent chromium-induced oxidative stress in mice liver tissue. Biol Trace Elem Res 125:46–58CrossRefGoogle Scholar
  7. Budhram R, Pandya KG, Lau-Cam CA (2013) Protection by taurine and thiotaurine against biochemical and cellular alterations induced by diabetes in a rat model. Adv Exp Med Biol 775:321–343CrossRefGoogle Scholar
  8. Chen B, Arnold LL, Cohen SM, Thomas DJ, Le XC (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. Toxicol Sci 124:320–326CrossRefGoogle Scholar
  9. Das J, Ghosh J, Manna P, Sil PC (2010) Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway. PLoS One 5:e12602CrossRefGoogle Scholar
  10. Das J, Roy A, Sil PC (2012) Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review. Food Funct 3:1251–1264CrossRefGoogle Scholar
  11. Gao S, Duan X, Wang X, Dong D, Liu D, Li X, Sun G, Li B (2013) Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol 59:739–747CrossRefGoogle Scholar
  12. Heidari R, Babaei H, Eghbal MA (2014) Amodiaquine-induced toxicity in isolated rat hepatocytes and the cytoprotective effects of taurine and/or N-acetyl cysteine. Res Pharm Sci 9:97–105PubMedPubMedCentralGoogle Scholar
  13. Higuchi M, Celino FT, Shimizu-Yamaguchi S, Miura C, Miura T (2012) Taurine plays an important role in the protection of spermatogonia from oxidative stress. Amino Acids 43:2359–2369CrossRefGoogle Scholar
  14. Hwang DF, Wang LC (2001) Effect of taurine on toxicity of cadmium in rats. Toxicology 167:173–180CrossRefGoogle Scholar
  15. Hwang DF, Wang LC, Cheng HM (1998) Effect of taurine on toxicity of copper in rats. Food Chem Toxicol 36:239–244CrossRefGoogle Scholar
  16. Jain A, Yadav A, Bozhkov AI, Padalko VI, Flora SJ (2011) Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats. Ecotoxicol Environ Saf 74:607–614CrossRefGoogle Scholar
  17. Li S, Yang L, Dong G, Wang X (2017) Taurine protects mouse liver against arsenic-induced apoptosis through JNK pathway. Adv Exp Med Biol 975:855–862CrossRefGoogle Scholar
  18. Mathew L, Vale A, Adcock JE (2010) Arsenical peripheral neuropathy. Pract Neurol 10:34–38CrossRefGoogle Scholar
  19. Meliker JR, Wahl RL, Cameron LL, Nriagu JO (2007) Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis. Environ Health 6:4CrossRefGoogle Scholar
  20. Mershiba SD, Dassprakash MV, Saraswathy SD (2013) Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats. Mol Biol Rep 40:3681–3691CrossRefGoogle Scholar
  21. Messarah M, Klibet F, Boumendjel A, Abdennour C, Bouzerna N, Boulakoud MS, El Feki A (2012) Hepatoprotective role and antioxidant capacity of selenium on arsenic-induced liver injury in rats. Exp Toxicol Pathol 64:167–174CrossRefGoogle Scholar
  22. Patrick L (2006) Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev 11:114–127PubMedGoogle Scholar
  23. Rodriguez-Lado L, Sun G, Berg M, Zhang Q, Xue H, Zheng Q, Johnson CA (2013) Groundwater arsenic contamination throughout China. Science 341:866–868CrossRefGoogle Scholar
  24. Tabassum H, Rehman H, Banerjee BD, Raisuddin S, Parvez S (2006) Attenuation of tamoxifen-induced hepatotoxicity by taurine in mice. Clin Chim Acta 370:129–136CrossRefGoogle Scholar
  25. Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Monnighoff I, Buchczyk D, Donner M, Flogel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Haussinger D (2006) Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J 20:574–576CrossRefGoogle Scholar
  26. Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Roth C, Witt M, Haussinger D (2007) Taurine deficiency and apoptosis: findings from the taurine transporter knockout mouse. Arch Biochem Biophys 462:202–209CrossRefGoogle Scholar
  27. Zhang Z, Liu D, Yi B, Liao Z, Tang L, Yin D, He M (2014) Taurine supplementation reduces oxidative stress and protects the liver in an iron-overload murine model. Mol Med Rep 10:2255–2262CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shuangxing Li
    • 1
  • Bin Kai Wei
    • 2
  • Jinhua Wang
    • 2
  • Guangtao Dong
    • 1
  • Xiujie Wang
    • 1
  1. 1.Department of Emergency SurgeryThe First Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Clinical Medicine (5+3), Dalian Medical UniversityDalianChina

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