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Taurine 11 pp 415-427 | Cite as

Perinatal Taurine Supplementation Prevents the Adverse Effects of Maternal Dyslipidemia on Growth and Cardiovascular Control in Adult Rat Offspring

  • Atcharaporn Thaeomor
  • Chonticha Tangnoi
  • Suphaket Seanthaweesuk
  • Nuntiya Somparn
  • Sanya RoysommutiEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Maternal dyslipidemia induces metabolic and cardiovascular disorders in adult offspring. This study tests the hypothesis that perinatal taurine supplementation prevents the adverse effects of maternal dyslipidemia on growth and cardiovascular function in adult rat offspring. Female Wistar rats were fed normal rat chow and water with (Dyslipidemia) or without dyslipidemia induction (Control) by intraperitoneal Triton WR-1339 injection, three times a week for 4 weeks. The female Control and Dyslipidemia rats were supplemented with (Control+T, Dyslipidemia+T) or without 3% taurine in water from conception to weaning. After weaning, male and female offspring were fed normal rat chow and water throughout the experiment. At 16 weeks of age, body weights significantly increased in male but not female Dyslipidemia compared to other groups, while visceral fat content significantly increased in both male and female Dyslipidemia groups. Further, both sexes displayed similar high fasting blood sugar and normal plasma leptin levels among the groups. While plasma total cholesterol and triglycerides significantly increased only in female Dyslipidemia, low-density lipoprotein cholesterol increased in both male and female Dyslipidemia groups. Mean arterial pressures and heart rates significantly increased, while baroreflex sensitivity decreased in male and female Dyslipidemia compared to all other groups. High-density lipoprotein cholesterol did not significantly different among male or female groups. These changes of the male and female Dyslipidemia group were ameliorated by perinatal taurine supplementation. The present study indicates that perinatal taurine supplementation prevents the adverse effects of maternal dyslipidemia on growth and cardiovascular function in both male and female, adult offspring.

Keywords

Baroreflex Hypercholesterolemia Hypertension Maternal dyslipidemia Perinatal taurine 

Abbreviations

BSHR

baroreflex sensitivity control of heart rate

Control+T

Control plus taurine supplementation

Dyslipidemia+T

Dyslipidemia plus taurine supplementation

HDL-C

high-density lipoprotein cholesterol

LDL-C

low-density lipoprotein cholesterol

PHE

phenylephrine

SNP

sodium nitroprusside

Notes

Acknowledgements

This work was supported by the Thailand Research Fund (TRF) TRG5880049 and the National Research Council Thailand (NRCT) SUT1-104-59-24-13, Thailand.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Atcharaporn Thaeomor
    • 1
  • Chonticha Tangnoi
    • 1
  • Suphaket Seanthaweesuk
    • 2
  • Nuntiya Somparn
    • 2
  • Sanya Roysommuti
    • 3
    Email author
  1. 1.School of Preclinic, Institute of ScienceSuranaree University of TechnologyNakhon RatchasimaThailand
  2. 2.Department of Preclinical Science, Faculty of MedicineThammasat UniversityPathumthaniThailand
  3. 3.Department of Physiology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand

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