Taurine 11 pp 261-271 | Cite as

Laxative Effects of Taurine on Loperamide-Induced Constipation in Rats

  • Dong-Sung Lee
  • Hee Geun Jo
  • Min Ji Kim
  • Hwan Lee
  • Sun Hee CheongEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


In the present study, we investigated the laxative effects of taurine in a rat model of loperamide-induced constipation. Rats were divided into six groups of six animals each: normal (NOR), control (CON), loperamide + Dulcolax (5.5 mg/kg, p.o.), and loperamide + various doses of taurine (7.5, 15, and 30 mg/kg, p.o.). Laxative activity was determined based on body weight, feeding characteristics, fecal properties, gastrointestinal transit (GIT) ratio, and the levels of serum gastrointestinal hormones. Taurine supplementation significantly increased the number, wet weight, and water content of fecal pellets in rats with loperamide-induced constipation. GIT ratio and loperamide-induced serum metabolic parameters, such as gastrin (GAS), motilin (MTL), and somatostatin (SS) significantly changed after supplementation with taurine in loperamide-induced constipated rats. We suggest that taurine had a potent effect against loperamide-induced constipation in part by increasing gastrointestinal motility.


Constipation Laxative effects Loperamide Taurine 



calcitonin gene related peptide




gastrointestinal transit







This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B01006822).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Dong-Sung Lee
    • 1
  • Hee Geun Jo
    • 2
  • Min Ji Kim
    • 2
  • Hwan Lee
    • 1
  • Sun Hee Cheong
    • 2
    Email author
  1. 1.College of PharmacyChosun UniversityDong-gu, GwangjuRepublic of Korea
  2. 2.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuRepublic of Korea

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