Taurine 11 pp 185-196 | Cite as

Antioxidant and Anti-Stress Effects of Taurine Against Electric Foot-Shock-Induced Acute Stress in Rats

  • Dong-Sung Lee
  • Hee Geun Jo
  • Min Ji Kim
  • Hwan Lee
  • Sun Hee CheongEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


In the present study, we evaluated the antioxidant and anti-stress activities of taurine in electric foot-shock stress model rats. Taurine supplementation markedly increased the hepatic glutathione (GSH) levels, compared to the levels in the stress group. In addition, activities of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were improved in the taurine-treated group. Plasma cortisol and dehydroepiandrosterone-sulfate (DHEA-S) levels were significantly reduced in the taurine-supplemented group compared to those in the stress group. In contrast, the levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were markedly increased in the taurine or betaine-treated group compared to those in the stress group. It may be concluded that taurine produces beneficial effects in the form of antioxidant status and biochemical alterations in foot-shock-induced acute stress in rats.


Antioxidant Anti-stress Electric foot-shock Taurine 



5-hydroxyindoleacetic acid




2-azobis (2-amidinopropane) hydrochloride






5-dimethyl-1-pyrroline N-oxide




Glutathione peroxidase






Superoxide dismutase





This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B01006822).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Dong-Sung Lee
    • 1
  • Hee Geun Jo
    • 2
  • Min Ji Kim
    • 2
  • Hwan Lee
    • 1
  • Sun Hee Cheong
    • 2
    Email author
  1. 1.College of PharmacyChosun UniversityDong-gu, GwangjuRepublic of Korea
  2. 2.Department of Marine Bio-Food SciencesChonnam National UniversityYeosuRepublic of Korea

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