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Taurine 11 pp 173-182 | Cite as

Taurine Regulation of Peripheral Hemodynamics

  • Francoise Sidime
  • Abdeslem El IdrissiEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)

Abstract

Taurine plays an important role in the modulation of cardiovascular function by acting not only within the brain but also within peripheral tissues. We found that IV injection of taurine to male rats caused hypotension and tachycardia. A single injection of taurine significantly lowered the systolic, diastolic and mean arterial pressure blood pressure in freely moving long Evans control rats. Previousely, we found that the endothelial cells express high levels of taurine transporters and GABAA receptors and showed that taurine activates GABAA receptors. Thus we suggest that the functional implication of GABAA receptors activation is the relaxation of the arterial muscularis, vasodilation and a decrease in blood pressure. Interestingly however, the effects of acute taurine injection were very different that chronic supplementation of taurine. When rats were supplemented taurine (0.05%, 4 weeks) in their drinking water, taurine has significant hypertensive properties. The increase in blood pressure was observed however only in females, males supplemented with taurine did not show an increase in systolic, diastolic or mean arterial pressure. In both genders however, taurine supplementation caused a significant tachycardia. Thus, we suggest that acute administration of taurine may be beneficial to lowering blood pressure. However, our data indicate that supplementation of taurine to females caused a significant increase in blood pressure. It remains to be seen the effect of taurine supplementation on hypertensive rats.

Keywords

Taurine supplementation Taurine GABA Vasoactivity Blood pressure Hypertension 

Abbreviations

TAU

taurine

GABA

γ-Aminobutyric acid

Notes

Acknowledgement

This work was supported by CDN, PSC-CUNY and CSI. The authors declare that they have no conflict of interest.This chapter was modified from the paper published by our group in Adv Exp Med Biol. (El Idrissi et al. 2013; 775:407–425). The related contents are re-used with the permission.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Biology, Center for Developmental NeuroscienceCollege of Staten IslandStaten IslandUSA

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