Taurine 11 pp 119-131 | Cite as

Preventive or Curative Administration of Taurine Regulates Lipid Metabolism in the Liver of Rats with Alcoholic Liver Disease

  • Riyi Tang
  • Qunhui Yang
  • Shumei Lin
  • Ying Feng
  • Jiancheng Yang
  • Qiufeng Lv
  • Gaofeng Wu
  • Jianmin Hu
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1155)


Excessive consumption causes alcoholic liver disease (ALD), which injures hepatocytes and induces imbalance of lipid metabolism. Taurine is known to protect the liver from various liver injuries, and relieve lipid profile. Our previous studies also found that taurine can prevent or cure ALD, reduce fat deposition, but the mechanism remains unclear. In the present study, ALD rat model was established by administration of alcohol, pyrazole and high fat diet. Two percent taurine was administered at the same time or after ALD model establishment. Serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), serum and hepatic TC, TG, HDL-C and LDL-C were analyzed. Real-Time RT-PCR was conducted to detect the mRNA expressions of fatty acid synthetase (FAS), acetyl-CoA catboxylase (ACC), carnitine palmitoyl transferase 1 (CPT-1), 3-Hydroxy-3-methyl glutaric acid acyl Coenzyme A reductase (HMGCR), peroxisome proliferators activated receptor α (PPARα) and sterol regulatory element-binding protein 1c (SREBP-1c). The results showed that serum ALT, AST, serum and hepatic TC, TG and LDL-C were higher, while HDL-C in ALD model rats was lower than normal rats, the changes of which can be significantly relieved by taurine administration. mRNA expressions of ACC, FAS, CPT-1, HMGCR, PPARα and SREBP-1c which were significantly changed by ethanol can also be regulated by taurine. The results indicated that taurine can prevent and repair hepatic injury of ALD rats and balance lipid metabolism indexes in the liver, the mechanisms may involves in the regulation of related enzymes and transcriptional regulators participated in lipid metabolism.


Taurine Alcoholic liver disease Lipid metabolism Rats 



alcoholic liver disease


alcoholic fatty liver disease


alcoholic hepatitis


alcoholic fibrosis


alcoholic cirrhosis


acetaldehyde dehydrogenase


aldehyde dehydrogenase




total cholesterol


low-density lipoprotein cholesterol


high-density lipoprotein cholesterol


alanine aminotransferase


aspartate aminotransferase


acetyl-CoA catboxylase


fatty acid synthetase


carnitine palmitoyl transferase 1


3-Hydroxy-3-methyl glutaric acid acyl Coenzyme A reductase


peroxisome proliferators activated receptor α


sterol regulatory element-binding protein 1c



This work was supported by the National Natural Science Foundation of China (No. 31772694, 31872441 and 31302051).


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Riyi Tang
    • 1
  • Qunhui Yang
    • 1
  • Shumei Lin
    • 1
  • Ying Feng
    • 1
  • Jiancheng Yang
    • 1
  • Qiufeng Lv
    • 1
  • Gaofeng Wu
    • 1
  • Jianmin Hu
    • 1
  1. 1.Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary MedicineShenyang Agricultural UniversityShenyangPeople’s Republic of China

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