Implications of HDACs in Neurological Disorders

  • Shabir Ahmad Ganai


Histone acetyl transferases (HATs) and histone deacetylases (HDACs), the functionally opposite enzymes, regulate the turnover of histone acetylation. This acetylation homeostasis in turn plays a key role in tuning gene expression. Aberrant activity of HDACs impairs this homeostasis resulting in transcriptional deregulation which in turn culminates in neuronal dysfunction. Here we discuss the implications of various HDACs in neurological disorders like Alzheimer’s disease, Huntington disease, Rett syndrome, and amyotrophic lateral sclerosis.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Shabir Ahmad Ganai
    • 1
  1. 1.Division of Basic Sciences and Humanities, Faculty of AgricultureSKUAST-KashmirWadura SoporeIndia

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