Epigenetic Enzymes and Drawbacks of Conventional Therapeutic Regimens
Post-translational modifications of histone proteins have noticeable role in passive chromatin remodelling. These modifications mainly include histone acetylation, methylation, phosphorylation etc. Methylation of DNA cytosine is also regarded as epigenetic modifications as it causes gene repression by recruiting HDACs. This chapter gives the bird’s eye view of writers and erasers of epigenetic modifications. Among the writers, special emphasis has been given to histone acetyl transferases, protein methyltransferases and DNA methyltransferases. Regarding erasers, histone deacetylases, demethylases and DNA demethylases are specially elaborated. Moreover, the current impediments in the therapeutic intervention of neurological disorders are also taken into account. Importantly, the drawbacks of traditional therapeutic regimens against the neurological complications will also be discussed.
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