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The Future of Precision Health & Integrated Diagnostics

  • Sanjiv Sam GambhirEmail author
Open Access
Conference paper

Abstract

Most of the world’s health care systems are focused on patients after they present with disease, and not before. While precision medicine uses personalized information to more effectively treat disease, the emerging field of precision health is situated to help assess disease risks, perform customized disease monitoring, and facilitate disease prevention and earlier disease detection. Currently an individual’s health is evaluated only a few times a year if at all, making it difficult to gather the amount of information needed to implement precision health. The emergence of continuous health monitoring devices with combined in vitro and in vivo(integrated)diagnostics, worn on the body and used in the home, will enable a clearer picture of human health and disease. However, challenges lie ahead in developing and validating novel monitoring technologies, and in optimizing data analytics to extract meaningful and actionable conclusions from continuous health data. This presentation will show some of the emerging technologies for diagnostics with a focus on cancer and the challenges to making precision health a reality in the decades to come. (Gambhir et al. 2018) (Slides 28.1, 28.2, and 28.3).

Disclosures

  • Relevant to this Talk
    • Endra Inc. – Founder, Visualsonics – SAB

    • Bracco – Consultant, MagArray – SAB

  • Others
    • ImaginAB, Click Diagnostics, Nine-Point Medical, GE Medical, Bayer, Site-One Therapeutics, Rio Inc., Sanofi Aventis, Piramal MI, Novartis, CellSight, Cytomx

Most of the world’s health care systems are focused on patients after they present with disease, and not before. While precision medicine uses personalized information to more effectively treat disease, the emerging field of precision health is situated to help assess disease risks, perform customized disease monitoring, and facilitate disease prevention and earlier disease detection. Currently an individual’s health is evaluated only a few times a year if at all, making it difficult to gather the amount of information needed to implement precision health. The emergence of continuous health monitoring devices with combined in vitro and in vivo(integrated)diagnostics, worn on the body and used in the home, will enable a clearer picture of human health and disease. However, challenges lie ahead in developing and validating novel monitoring technologies, and in optimizing data analytics to extract meaningful and actionable conclusions from continuous health data. This presentation will show some of the emerging technologies for diagnostics with a focus on cancer and the challenges to making precision health a reality in the decades to come (Gambhir et al. 2018) (Slides 28.1, 28.2, and 28.3).
Slide 28.1

The future: precision health

Slide 28.2

Patient diagnostics analogy with jet engines & sensors

Slide 28.3

The future of integrated diagnostics

Summary

  • The focus needs to shift to earlier detection of disease away from late stage disease

  • Scientists working on in vitro technologies need to work closely with those who work on molecular imaging

  • Strategies for signal amplification to detect fewer numbers of cells or their by-products are needed

  • Strategies for continuous sensing and wearable/implantable diagnostics need further development

  • Technology remains ahead of the biology

  • Technology needs to be developed to accelerate biological discovery

  • Biomarkers of EARLY disease need accelerated discovery and validation through novel nanotechnologies

  • Lower cost solutions are key from a global economic perspective

  • Collaboration between academics, government funding agencies, industry, foundations, and the FDA will help to test these approaches in pilot clinical trials

Special Thanks

  • Patients & Healthy Volunteers

  • National Cancer Institute
    • CCNE U54, PSOC U54, ICMIC P50, NTR U54

    • EDRN U01, ICBP U54, RO1’s, R21’s, R25T, T32’s

  • Canary Foundation

  • Ben & Catherine Ivy Foundation

  • Sir Peter Michael Foundation

  • GE/Bayer/Bracco/Google Life Sciences

  • Visualsonics/Endra/Optosonics

  • Fred Hutchinson Cancer Center

  • Molecular Imaging Program at Stanford (MIPS)

Supplementary material

Video S3-keynote

(MP4 739085 kb)

Reference

  1. Gambhir SS, Ge TJ, Vermesh O, Spitler R (2018) Toward achieving precision health. Sci Transl Med 10(430):eaao3612.  https://doi.org/10.1126/scitranslmed.aao3612. Review. PMID: 29491186CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© The Author(s) 2020

Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Authors and Affiliations

  1. 1.Stanford UniversityStanfordUSA

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