Virus Infection and Ophthalmic Diseases from the Perspective of Integrated Medicine

  • Yun Feng
Part of the Advances in Visual Science and Eye Diseases book series (AVSED, volume 3)


We are surrounded by viruses, a common pathogen that can cause all kinds of diseases. Doctors are very familiar with virus infections as it is ubiquitous. Viruses can infect the eye from the ocular surface to the fundus. Herpes zoster virus (HZV) and herpes simplex virus (HSV) infection for instance can cause blepharitis, conjunctivitis, keratitis, scleritis, anterior uveitis, glaucoma, vitritis, and retinal inflammation. On the one hand, the virus attacks the target organ directly and cause serious consequences, such as acute retinal necrosis, and necrotizing keratitis. On the other hand, it can trigger the body’s immune response and cause such as keratitis disciformis. Viral eye diseases are difficult to treat. Not only virus infections can happen acutely and can cause serious damage to the eye tissue, but also it can be recurrent. It is a difficult situation that both doctors and patients find hard to deal with. However, if we try to see the problem from the perspective of integrated medicine, we might have more new ideas and new therapy methods.


  1. 1.
    de Visser L, Braakenburg A, Rothova A, de Boer JH. Rubella virus-associated uveitis: clinical manifestations and visual prognosis. Am J Ophthalmol. 2008;146:292–7.CrossRefPubMedGoogle Scholar
  2. 2.
    van Boxtel LA, van der Lelij A, van der Meer J, et al. Cytomegalovirus as a cause of anterior uveitis in immunocompetent patients. Ophthalmology. 2007;114:1358 1362.Google Scholar
  3. 3.
    de Schryver I, Rozenberg F, Cassoux N, et al. Diagnosis and treatment of cytomegalovirus iridocyelitis without retinal necrosis. Br J Ophthalmol. 2006;90:852–5.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Koizumi N, Suzuki T, Uno T, et al. Cytomegalovirus as an etiologic factor in corneal endotheliitis. Ophthalmology. 2008;115:292–7.CrossRefPubMedGoogle Scholar
  5. 5.
    Chee SP, Jap A. Immune ring formation associated with cytomegalovirus endotheliitis. Am J Ophthalmol. 2011;152:449–553.CrossRefPubMedGoogle Scholar
  6. 6.
    Khodadoust AA, Attarzadeh A. Presumed autoimmune corneal endotheliopathy. Am J Ophthalmol. 1982;93:718–22.CrossRefPubMedGoogle Scholar
  7. 7.
    Carmichael A. Cytomegalovirus and the eye. Eye Reaction (Lond). 2012;26:237–40.CrossRefGoogle Scholar
  8. 8.
    Nakamura T, Ishikawa F, Sonoda KH, et al. Characterization and distribution of bone marrow derived cells in mouse cornea. Invest Ophthalmol Vis Sci. 2005;46:497–503.CrossRefPubMedGoogle Scholar
  9. 9.
    Shiraishi Hiraishi A, Hara Y, Takahashi M, et al. Demonstration of “Owl’s” eye morphology by confocal microscopy in a patient with presumed cytomegalovirus corneal endotheliitis. Am J Ophthalmol. 2007;143:715–7.CrossRefGoogle Scholar
  10. 10.
    Suzuki T, Ohashi Y. Corneal endotheliitis. Semin Ophthalmol. 2008;23:235–40.CrossRefPubMedGoogle Scholar
  11. 11.
    Kandofi M, Inoue T, Takamatsu F, et al. Prevalence and features of keratitis with quantitative polymerase chain reaction positive for cytomegalovirus. Ophthalmology. 2010;117:216–22.CrossRefGoogle Scholar
  12. 12.
    Meffert SA, Kertes PJ, Lim PL, Conway MD, Peyman GA. Successful treatment of progressive outer retinal necrosis using high-dose intravitreal ganciclovir. Retina. 1997;17(6):560–2.CrossRefPubMedGoogle Scholar
  13. 13.
    Luu KK, Scott IU, Chaudhry NA, Verm A, Davis JL. Intravitreal antiviral injections as adjunctive therapy in the management of immunocompetent patients with necrotizing herpetic retinopathy. Am J Ophthalmol. 2000;129(6):811–3.CrossRefPubMedGoogle Scholar
  14. 14.
    Chau TTH, Cassoux N, Bodaghi B, Lehoang P. Successful treatment with combination of systemic antiviral drugs and intravitreal ganciclovir injections in the management of severe necrotizing herpetic retinitis. Ocul Immunol Inflamm. 2003;11(2):141–4.CrossRefGoogle Scholar
  15. 15.
    Teoh SC, Ou X, Lim TH. Intravitreal ganciclovir maintenance injection for cytomegalovirus retinitis: efficacy of a low-volume, intermediate-dose regimen. Ophthalmology. 2012;119(3):588–95.CrossRefPubMedGoogle Scholar
  16. 16.
    Arevalo JF, Garcia RA, Mendoza AJ. High-dose (5000-microg) intravitreal ganciclovir combined with highly active antiretroviral therapy for cytomegalovirus retinitis in HIV-infected patients in Venezuela. Eur J Ophthalmol. 2005;15(5):610–8.CrossRefPubMedGoogle Scholar
  17. 17.
    Surachatkumtonekul T, Chokephaibulkit K, Vanprapar N, Pamonvaechavan P. Treatment of cytomegalovirus (CMV) retinitis with intravitreous ganciclovir in HIV-infected children. J Med Assoc Thail. 2008;91(3):331–7.Google Scholar

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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2020

Authors and Affiliations

  • Yun Feng
    • 1
  1. 1.Department of OphthalmologyPeking University Third HospitalBeijingChina

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