Laboratory Diagnosis of Microangiopathic Hemolytic Anemia Including TTP, DIC, and HUS

  • Aakanksha Singh
  • Mrinalini Kotru


A wide variety of disorders lead to red cell fragmentation, where microangiopathies come to light upon incidental laboratory diagnosis or with catastrophic clinical presentation. Microangiopathic hemolytic anemia is often the “symptom” or “manifestation” of an underlying activated endothelium or platelet secondary to myriad possibilities. The laboratory work up of disorders under this umbrella term is complex and individualised. Our recent understanding into their pathogenesis has led to better distinction of diseases previously misdiagnosed as another.

Suggested Reading

  1. 1.
    Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017;129(21):2836–46.CrossRefGoogle Scholar
  2. 2.
    Jokiranta TS. HUS and atypical HUS. Blood. 2017;129(21):2847–56.CrossRefGoogle Scholar
  3. 3.
    Masias C, Vasu S, Cataland SR. None of the above: thrombotic microangiopathy beyond TTP and HUS. Blood. 2017;129(21):2857–63.CrossRefGoogle Scholar
  4. 4.
    Kerr H, Richards A. Complement-mediated injury and protection of endothelium: lessons from atypical haemolytic uraemic syndrome. Immunobiology. 2012;217(2):195–203.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Aakanksha Singh
    • 1
  • Mrinalini Kotru
    • 1
  1. 1.Department of PathologyUniversity College of Medical Sciences and GTB HospitalNew DelhiIndia

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