Advertisement

Megaloblastic Anemia and Dual Nutritional Deficiency Anemia

  • K. V. Karthika
  • Hara Prasad Pati
Chapter

Abstract

Megaloblastic anemia is a general term used to describe a group of anemias caused by impaired DNA synthesis and characterized by macro-ovalocytes in peripheral blood smear and megaloblastic erythroid hyperplasia in the bone marrow.

Keywords

Vitamin B12 Folate Iron Megaloblastic anemia Causes Diagnosis Treatment Dimorphic anemia 

References

  1. 1.
    Pitkin RM, Allen LB, Bailey LB, et al. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline. Washington: National Academies Press; 1998.Google Scholar
  2. 2.
    Butler CC, Vidal-Alaball J, Cannings-John R, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. Fam Pract. 2006;23:279–85.CrossRefGoogle Scholar
  3. 3.
    Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010;49:535–48.CrossRefGoogle Scholar
  4. 4.
    Verhoef H, Veenemans J, Mwangi M, Prentice AM. Safety and benefits of interventions to increase folate status in malaria-endemic areas. Br J Haematol. 2017;177(6):905–18.CrossRefGoogle Scholar
  5. 5.
    Carmel R, Green R, Rosenblatt DS, et al. Update on cobalamin, folate, and homocysteine. Hematology Am Soc Hematol Educ Program. 2003;62:81.Google Scholar
  6. 6.
    Lieberman M, Marks AD. Tetrahydrofolate, vitamin B12, and S-adenosylmethionine. Mark’s basic medical biochemistry: a clinical approach. 3rd ed. Philadelphia: Wolters Kluwer/Lippincott Williams &Wilkins; 2009.Google Scholar
  7. 7.
    Kumar V, Abbas AK, Aster JC. Robbins and Cotran. Pathologic basis of disease. 9th ed. Philadelphia: Elsevier Saunders; 2015.Google Scholar
  8. 8.
    Truswell AS. Vitamin B12. Nutr Diet. 2007;64:S120–5.CrossRefGoogle Scholar
  9. 9.
    Hemmer B, Glocker FX, Schumacher M, et al. Subacute combined degeneration: clinical, electrophysiological, and magnetic resonance imaging findings. J Neurol Neurosurg Psychiatry. 1998;65:822–7.CrossRefGoogle Scholar
  10. 10.
    Green R, Kinsella LJ. Current concepts in the diagnosis of cobalamin deficiency. Neurology. 1995;45:1435–40.CrossRefGoogle Scholar
  11. 11.
    Andres E, Fothergill H, Mecili M. Efficacy of oral cobalamin (vitamin B12) therapy. Expert Opin Pharmacother. 2010;11(2):249–56.CrossRefGoogle Scholar
  12. 12.
    Patel KV. Epidemiology of anemia in older adults. Semin Hematol. 2008;45(4):210–7.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • K. V. Karthika
    • 1
  • Hara Prasad Pati
    • 1
  1. 1.Department of HematologyAll India Institute of Medical SciencesNew DelhiIndia

Personalised recommendations