Autoimmune Myelofibrosis: A Diagnosis by Exclusion

  • Preeti Tripathi
  • Shivangi J. Harankhedkar
  • Hara Prasad Pati


Myelofibrosis or bone marrow (BM) fibrosis is a common phenomenon occurring with various benign and malignant disorders. Neoplastic causes of BM fibrosis include various myeloproliferative neoplasms (MPNs), acute megakaryocytic leukemia, lymphoid malignancies, and metastasis of various solid malignancies. Non-neoplastic causes of BM fibrosis include chronic infections (e.g., tuberculosis, kala azar), metabolic causes, storage disorders, drug reactions, and autoimmune disorders [1]. Despite varied etiology and pathogenesis, it is the aberrant production of the fibrogenic cytokines, which is the main cause mediating the fibrosis of BM through stimulation of BM fibroblasts [1].


Autoimmune Myelofibrosis Systemic lupus erythomatosus Steroids primary myelofibrosis 


Conflicts of Interest



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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Preeti Tripathi
    • 1
  • Shivangi J. Harankhedkar
    • 1
  • Hara Prasad Pati
    • 2
  1. 1.D.M. HematopathologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of HematologyAll India Institute of Medical SciencesNew DelhiIndia

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