Radioimmunoimaging and Targeted Therapy

  • Yafu Yin
  • Steven Rowe


More than 20 years ago, Dr. Zhu from China said, “As the world-renowned achievements of radioimmunoassay for trace substance detection are attributed to the multidisciplinary effect of nuclear medicine and immunology, likewise, success of radioimmunoimaging (RII) and radioimmunotherapy (RIT) are dependent on the interaction of these two disciplines, which opens up a new way for the diagnosis and treatment of cancer.” RII and RIT, together termed radioimmunotheranostics, are characterized by radioisotope-labeled antibody or fragments which can recognize some specific antigen; the ultimate goal of which is to diagnose or treat cancer or other diseases. Radioimmunotheranostics has a 70-year history of development, and numerous scholars who came from diverse fields including medicine, immunology, bioengineering, etc. dedicated in this field made unremittent efforts for human health. With the rapid development of medical and bioengineering technology, novel theranostic probes, which can recognize a specific antigen on the cancer cell or are associated with the tumor microenvironment, are not limited to antibodies but include some small-molecule ligands. In this chapter, we would also give some introduction of radionuclide-labeled non-antibody imaging and therapy, while the major focus will be on traditional RII and RIT.


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Copyright information

© Springer Nature Singapore Pte Ltd. and Shanghai Jiao Tong University Press 2019

Authors and Affiliations

  • Yafu Yin
    • 1
  • Steven Rowe
    • 2
  1. 1.Department of Nuclear MedicineXinhua Hospital, Shanghai Jiao Tong University School of MedicineShanghaiP. R. China
  2. 2.The Russell H. Morgan Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineBaltimoreUSA

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