Coronin: An Overview

  • Samridhi Pathak
  • Ricka Gauba
  • Sarath Chandra Dantu
  • Avinash KaleEmail author


Coronin is one of the complex proteins involved in the acting polymerization cascade. It is a multidomain protein which is known to have been involved in diverse functions across higher eukaryotes. There had been lots of literature available which provide different modes of classification of coronins, which is quite confusing for the readers. In the current chapter, we have summarized the distinct classification systems for coronin that are available in the literature and how they co-relate with one another. Further, we discuss various structural aspects known for the coronin. Till date very little is known about this protein from the prospective of apicomplexans as majority of work has been focused upon higher eukaryotes. Finally, we talk about the interaction of coronin with actin on the basis of available literature.

Supplementary material

480865_1_En_8_MOESM1_ESM.xlsx (57 kb)
ST_CRN-1 Sequence comparison identity matrix for coronin proteins used in the current study (XLSX 57 kb)


  1. 1.
    Morgan RO, Fernandez MP (2008) Molecular phylogeny and evolution of the coronin gene family. Subcell Biochem 48:41–55. CrossRefPubMedGoogle Scholar
  2. 2.
    Cai L, Makhov AM, Bear JE (2007) F-actin binding is essential for coronin 1B function in vivo. J Cell Sci 120.(Pt 10:1779–1790. CrossRefPubMedGoogle Scholar
  3. 3.
    De Hostos EL (1999) The coronin family of actin-associated proteins. Trends Cell Biol 9(9):345–350. CrossRefPubMedGoogle Scholar
  4. 4.
    Eckert C, Hammesfahr B, Kollmar M (2011) A holistic phylogeny of the coronin gene family reveals an ancient origin of the tandem-coronin, defines a new subfamily, and predicts protein function. BMC Evol Biol 11(1):268. CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    McArdle B, Hofmann A (2008) Coronin structure and implications. Subcell Biochem 48:56–71. CrossRefPubMedGoogle Scholar
  6. 6.
    Xavier CP, Eichinger L, Fernandez MP et al (2008) Evolutionary and functional diversity of coronin proteins. Subcell Biochem 48:98–109CrossRefGoogle Scholar
  7. 7.
    Hudson AM, Cooley L (2000) Phylogenetic, structural and functional relationships between WD-and Kelch-repeat proteins. NCBI booksheifGoogle Scholar
  8. 8.
    Appleton BA, Wu P, Wiesmann C (2006) The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Structure 14(1):87–96. CrossRefPubMedGoogle Scholar
  9. 9.
    Bear JE, Clemen CS, Cooley L, et al (2008) The coronin family of proteinsGoogle Scholar
  10. 10.
    Olshina MA, Angrisano F, Marapana DS et al (2015) Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites. Malar J 14(1):280. CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Humphries CL, Balcer HI, D’Agostino JL et al (2002) Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin. J Cell Biol 159(6):993–1004. CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Pollard TDT (2007) Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct 36:451–477. CrossRefPubMedGoogle Scholar
  13. 13.
    Tilley FC, Williamson RC, Race PR et al (2015) Integration of the Rac1- and actin-binding properties of Coronin-1C Integration of the Rac1- and actin-binding properties of Coronin-1C. 1248(January 2016).
  14. 14.
    Salamun J, Kallio JP, Daher W, Soldati-Favre D et al (2014) Tructure of toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress. FASEB J 28(11):4729–4747CrossRefGoogle Scholar
  15. 15.
    Gandhi M, Jangi M, Goode BL (2010) Functional surfaces on the actin-binding protein coronin revealed by systematic mutagenesis. J Biol Chem 285(45):34899–34908. CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Gatfield J, Albrecht I, Zanolari B, Steinmetz MO, Pieters J (2005) Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Mol Biol Cell 16(6):2786–2798. CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Goode BL, Wong JJ, Butty AC et al (1999) Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast. J Cell Biol 144(1):83–98. CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Gandhi M, Goode BL (2008) Coronin: the double-edged sword of actin dynamics. Subcell Biochem. 48:72–87CrossRefGoogle Scholar
  19. 19.
    Chan KT, Roadcap DW, Holoweckyj N, Bear JE (2012) Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. 96:89–96.
  20. 20.
    Liu CZ, Chen Y, Sui SF (2006) The identification of a new actin-binding region in p57. Cell Res 16(1):106–112. CrossRefPubMedGoogle Scholar
  21. 21.
    Hunter S, Jones P, Mitchell A et al (2012) InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res 40(D1):306–312. CrossRefGoogle Scholar
  22. 22.
    Kueh HY, Charras GT, Mitchison TJ, Brieher WM (2008) Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol 182(2):341–353. CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Gandhi M, Achard V, Blanchoin L, Goode BL (2009) Coronin switches roles in actin disassembly depending on the nucleotide state of actin. Mol Cell 34(3):364–374. CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I (2014) Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress. FASEB J 28(11):4729–4747. CrossRefPubMedGoogle Scholar
  25. 25.
    Ge P, Durer ZAO, Kudryashov D, Zhou ZH, Reisler E (2014) Cryo-EM reveals different coronin binding modes for ADP– and ADP–BeFx actin filaments. Nat Struct Mol Biol 21(12):1075–1081. CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Pollard TD (2007) Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct 36:451–477. CrossRefPubMedGoogle Scholar
  27. 27.
    Lin M-C, Galletta BJ et al (2010) Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo. J Cell Sci 123(8):1329–1342CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Samridhi Pathak
    • 1
  • Ricka Gauba
    • 1
  • Sarath Chandra Dantu
    • 2
  • Avinash Kale
    • 1
    Email author
  1. 1.School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS)MumbaiIndia
  2. 2.Department of Computer Science, Synthetic Biology ThemeBrunel University LondonUxbridgeUK

Personalised recommendations