Capping Protein (CP): The Formin Competitor

  • Samridhi Pathak
  • Ricka Gauba
  • Sarath Chandra Dantu
  • Avinash KaleEmail author


Capping protein (CP) is a 62 kDa heterodimer, composed of Cpα and Cpβ subunits of approximately 31 kDa each. CP has been known to bind to the barbed end of the actin protofilament, thereby controlling filament growth by inhibiting monomer addition or loss from that end. In the current chapter, we discuss about the various isoforms of CP proteins known to us. Further, we summarize the distinct structural aspects know about the heterodimer, especially that of higher eukaryotes. Later on we present the mode of action of CP on actin followed by sequence-based structural analysis of various higher eukaryotic species. Finally, we sum up by discussing various regulators of CP.

Supplementary material

480865_1_En_7_MOESM1_ESM.xlsx (61 kb)
ST_CP-1 Sequence comparison identity matrix for CPα proteins used in the current study (XLSX 61 kb)
480865_1_En_7_MOESM2_ESM.xlsx (50 kb)
ST_CP-2 Sequence comparison identity matrix for CPβ proteins used in the current study (XLSX 50 kb)
480865_1_En_7_MOESM3_ESM.xlsx (15 kb)
ST_CP-3 ScanProsite analysis of CPα sequences for searching regulatory protein binding motifs (XLSX 14 kb)
480865_1_En_7_MOESM4_ESM.xlsx (13 kb)
ST_CP-4 ScanProsite analysis of CPβ sequences for searching regulatory protein binding motifs (XLSX 13 kb)
480865_1_En_7_MOESM5_ESM.xlsx (8 kb)
ST_CP-5 ScanProsite analysis of CPα and CPβ sequences for searching regulatory protein binding motifs in apicomplexan formins (XLSX 8 kb)


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Samridhi Pathak
    • 1
  • Ricka Gauba
    • 1
  • Sarath Chandra Dantu
    • 2
  • Avinash Kale
    • 1
    Email author
  1. 1.School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS)MumbaiIndia
  2. 2.Department of Computer Science, Synthetic Biology ThemeBrunel University LondonUxbridgeUK

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