CAP (Cyclase-Associated Protein): The Silent Worker

  • Samridhi Pathak
  • Ricka Gauba
  • Sarath Chandra Dantu
  • Avinash KaleEmail author


In the current chapter, we provide an overview of the CAP (cyclase-associated protein) and its salient features in regulating the actin-mediated gliding motility. It is one of the highly conserved, multi-domain proteins involved in regulating the actin dynamics. Unlike the eukaryotic counterparts, CAPs in apicomplexan do not possess different isoform and lack the upstream N-terminal domain indicating a differential regulatory function. As observed in our study, CAP in apicomplexan showed lack of unique consensus motif important for actin binding except for Plasmodium vivax.

Supplementary material

480865_1_En_6_MOESM1_ESM.xlsx (63 kb)
ST_CAP-1 Sequence comparison identity matrix for CAP proteins used in the current study (XLSX 62 kb)


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Samridhi Pathak
    • 1
  • Ricka Gauba
    • 1
  • Sarath Chandra Dantu
    • 2
  • Avinash Kale
    • 1
    Email author
  1. 1.School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS)MumbaiIndia
  2. 2.Department of Computer Science, Synthetic Biology ThemeBrunel University LondonUxbridgeUK

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