ADF (Actin Depolymerizing Factor): The Breaker of the Polymer in Homeostasis

  • Samridhi Pathak
  • Ricka Gauba
  • Sarath Chandra Dantu
  • Avinash KaleEmail author


This chapter talks about the various isoforms of ADF that exist in different higher eukaryotes and its variation from apicomplexan ADF. We have discussed the structure, the function and the stability of the protein and the way it is regulated in different actin-mediated cellular processes to control the machinery of actin polymerization. ADF, an actin depolymerizing factor which exist in two isoforms in Plasmodium, has been well-studied in the current chapter. The structural difference of ADF from apicomplexan to its higher eukaryotic counterparts has been elucidated in this chapter. We have deduced a unique motif present in the apicomplexan ADF and have discussed about its plausible role in the regulation of actin depolymerization process. Finally, we also have briefed about the various regulators of ADF known in the literature.

Supplementary material

480865_1_En_5_MOESM1_ESM.pdf (35 kb)
SF_ADF-1 The detailed alignment of all ADF1 and ADF2 from Plasmodium family with human cofilin (PDF 35 kb)
480865_1_En_5_MOESM2_ESM.xlsx (63 kb)
ST_ADF-1 Sequence comparison identity matrix for ADF proteins used in the current study (XLSX 63 kb)


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Samridhi Pathak
    • 1
  • Ricka Gauba
    • 1
  • Sarath Chandra Dantu
    • 2
  • Avinash Kale
    • 1
    Email author
  1. 1.School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS)MumbaiIndia
  2. 2.Department of Computer Science, Synthetic Biology ThemeBrunel University LondonUxbridgeUK

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