Advertisement

Actin Polymerization in Apicomplexans: A Novel Perspective

  • Samridhi Pathak
  • Ricka Gauba
  • Avinash KaleEmail author
Chapter

Abstract

In the current chapter, we summarize the major/novel findings that we had reported in the previous sections. We also provide the novel perspective about individual partners known to regulate actin polymerization/depolymerization in apicomplexans. We also summarize the major findings of our mathematical model, which is mainly highlighted on how and what helps cells to maintain an average size of the actin filaments within a species. This is particularly important, since excessive growth of filament can lead to cell lysis. Finally, we present our conclusions about the probable evolutionary pathway of actin and its regulators in apicomplexans, based on the current literature and our phylogeny analysis.

Bibliography

  1. 1.
    Lambrechts A, Van Troys M, Ampe C (2004) The actin cytoskeleton in normal and pathological cell motility. Int J Biochem Cell Biol 36(10):1890–1909.  https://doi.org/10.1016/j.biocel.2004.01.024CrossRefPubMedGoogle Scholar
  2. 2.
    Soldati-Favre D (2008) Molecular dissection of host cell invasion by the apicomplexans: the glideosome. Parasite 15(3):197–205.  https://doi.org/10.1051/parasite/2008153197CrossRefPubMedGoogle Scholar
  3. 3.
    Opitz C, Soldati D (2002) “The glideosome”: a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii. Mol Microbiol 45(3):597–604.  https://doi.org/10.1046/j.1365-2958.2002.03056.xCrossRefPubMedGoogle Scholar
  4. 4.
    Hunter S, Jones P, Mitchell A et al (2012) InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res 40(D1):306–312.  https://doi.org/10.1093/nar/gkr948CrossRefGoogle Scholar
  5. 5.
    Prajapat M, Pathak S, Gauba R, Kale A, Saini S (2018) Mathematical modelling of actin treadmill in Apicomplexans. bioRxiv 2018(February):1–30.  https://doi.org/10.1101/258913CrossRefGoogle Scholar
  6. 6.
    Madden T (2002) The BLAST sequence analysis tool. NCBI Handb [Internet]. 2002:1–18Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS)MumbaiIndia

Personalised recommendations