Agarwood: Medicinal Side of the Fragrant Plant
Agarwood is considered primarily to be a source of fragrant resins which is used in perfumery. However, its medical attributes are equally important but remains overshadowed by the popularity of its aroma, which is attractive both as a flavor and fragrance ingredient as well as for the economic value it posesses. The divide between the Eastern and the Western world with regard to its fragrant versus medicinal use has also restricted R&D in on the medicinal aspect of agarwood. This chapter is an attempt to look at the medicinal side of the fragrant plant. The phytoconstituent profile of agarwood and its use in traditional therapy are reviewed and current research on pharmacological and toxicological aspects is discussed elaborately to give an overview of the present understanding of the medicinal nature of agarwood. The ultimate aim of this effort is to prime and synergise more research thinking on this neglected aspect that can ultimately lead to identification and synthesis of novel medicinal molecules and therapies from agarwood.
KeywordsAquilaria Traditional knowledge Pharmacological activity Phytoconstituents Toxicity
- Alam J, Mujahid M, Rahman M, Akhtar J, Khalid M, Jahan Y, Basit A, Khan A, Shawwal M, Iqbal SS. An insight of pharmacognostic study and phytopharmacology of Aquilaria agallocha. J Appl Pharm Sci. 2015;5:173–81.Google Scholar
- Alla T, Handral M, Nandakumar K, Venkatrao N, Shalam S, Shantakumar SM. Anxiolytic and anticonvulsant activity of alcoholic extract of heartwood of Aquilaria agallocha roxb, (Thymelaeceae) in mice. Pharmacology. 2007;2:218–25.Google Scholar
- Batubara R, Surjanto S, Sihombing TM, Ginting H. The safety of tea agarwood (Aquilaria malaccensis) from tree induction through test of toxicity subchronic oral 90 days. Biofarmasi. 2016;14(2):69–76.Google Scholar
- Chakrabarty K, Kumar A, Menon V. Trade in Agarwood. New Delhi: TRAFFIC India and WWF-India; 1994. p. 51.Google Scholar
- Chitre T, Bhutada P, Nandakumar K, Somani R, Miniyar P, Mundhada Y, Gore S, Jain K. Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals. Pharmacology. 2007;1:288–98.Google Scholar
- CITES, UNEP-WCMC Species Database: CITES-Listed Species; 2018. www.cites.org. Accessed 10 Sep 2018.
- Dahham SS, Hassan LE, Ahamed MB, Majid AS, Majid AM, Zulkepli NN. In vivo toxicity and antitumor activity of essential oils extract from agarwood (Aquilaria crassna). BMC Complement Altern Med. 2016a;16:236.Google Scholar
- Dash M, Patra JK, Panda PP. Phytochemical and antimicrobial screening of extracts of Aquilaria agallocha Roxb. Afr J Biotechnol. 2008;7:3531–4.Google Scholar
- Duan Z, Li W, Dou Z, Xie H, He A, Shi M. Extraction and antioxidant activity of flavonoids from Aquilaria sinensis (Lour.) Gilg leaves. J Food Sci. 2015;36:45–50.Google Scholar
- Fratkin J. Chinese herbal patent formulas: a practical guide. Colorado: Shya Publications; 1994.Google Scholar
- Haslett C, Chilvers ER, Boon NA, Colledge NR, Hunter JA. Side effects of NSAIDS. In: Davidson’s Principles and Practice of Medicine. Edinburgh: Churchill Livingstone; 2002. p. 989–90.Google Scholar
- Hendra H, Moeljopawiro S, Nuringtyas TR. Antioxidant and antibacterial activities of agarwood (Aquilaria malaccensis Lamk.) leaves. AIP Conf Proc. 2016;1755(1):140004.Google Scholar
- Huang J, Chen H, Yu Z, Zhou Y, Ning G. Effects of different ratios of Aquilaria sinensis leaf meal on the growth performance, slaughter performance and nutrients digestibility of broiler. China Feed. 2016;11:36–42.Google Scholar
- Hussain T, Al-Attas OS, Al-Daghri NM, Mohammed AA, Rosas ED, Ibrahim S, Vinodson B, Ansari MG, El-Din KIA. Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke. Mol Cell Biochem. 2014;391:127–36.CrossRefGoogle Scholar
- IUCN, IUCN Red List of Threatened Species; 2018. https://www.iucnredlist.org. Accessed 17 Nov 2018.
- Jermsri P, Kumphune S. Ethyl acetate extract of Aquilaria crassna preserve actin cytoskeleton on simulated ischemia induced cardiac cell death. J Med Plants Res. 2012;6(23):4057–62.Google Scholar
- Jermsri P, Jiraviriyakul A, Unajak S, Kumphune S. Effects of Aquilaria crassna crude extract on simulated ischemia induced cardiac cell death. Int J Pharm Bio Sci. 2012;3(3):604–13.Google Scholar
- Jung D. The value of agarwood. Reflections upon its use and history in south Yemen. Extended Version of a talk given at the Workshop “The Use of Herbs in Yemeni Healing Practices,” Halle, September 25–26, 2009. https://archiv.ub.uni-heidelberg.de/volltextserver/12039/.
- Kakino M, Hara H. Pharmacological effects of Aquilaria spp. leaves and their chemical constituents. In: Mohamed R, editor. Agarwood-Science behind the fragrance. Singapore: Springer; 2016. p. 125–36.Google Scholar
- Khalil AS, Rahim AA, Taha KK, Abdallah KB. Characterization of methanolic extracts of agarwood leaves. J Archaeol Sci. 2013;1:78–88.Google Scholar
- Li H, Jiang Z, Mei Q. Comparative study on the effect of Aquilaria sinensis leaf tea and agarwood on promoting small intestine propulsion. Asia-Pacific Tradit Med. 2013;9:24–5.Google Scholar
- Lin FH, Peng YH, Ke FF, Deng YL. Experimental study on the content, antioxidant activity in vitro, and delaying aging effect of tannins from the leaf of Aquilaria sinensis (Lour.) Gilg. J Guangdong Pharm Univer. 2012;3:011.Google Scholar
- Liu MC, Bleecker ER, Lichtenstein LM, Kagey-Sobotka A, Niv Y, McLemore TL, Permutt S, Proud D, Hubbard WC. Evidence for elevated levels of histamine, prostaglandin D2, and other broncho constricting prostaglandins in the airways of subjects with mild asthma. Am Rev Respir Dis. 1990;142(1):126–32.CrossRefGoogle Scholar
- Oldfield S, Lusty C, MacKinven A. The word list of threatened trees. Cambridge: World Conservation Press; 1998. p. 650.Google Scholar
- Pranakhon R, Pannangpetch P, Aromdee C. Antihyperglycemic activity of agarwood leaf extracts in STZ-induced diabetic rats and glucose uptake enhancement activity in rat adipocytes. Songklanakarin J Sci Technol. 2011;33(4):405–10.Google Scholar
- Radosevic I. Uses and benefits for agarwood essential oil; 2018. http://www.balancemebeautiful.com/uses-and-benefits-for-agarwood-essential-oil. Accessed 15 Feb 2018.
- Rahman H, Vakati K, Eswaraiah MC. In-vivo and in-vitro anti-inflammatory activity of Aquilaria agallocha oil. Int J Basic Med Sci Pharm. 2012;2:7–10.Google Scholar
- Rahman H, Eswaraiah MC, Dutta AM. Anti-arthritic activity of leaves and oil of Aquilaria agallocha. Haya Saudi J Life Sci. 2016a;1:34–43.Google Scholar
- Ritter JM. Anti-inflammatory and immunosuppressive drugs. In: Rang HP, Dale MM, editors. Pharmacology. Edinburgh: Churchill Livingston; 2000. p. 229–32.Google Scholar
- Said F, Kamaluddin MT. Efficacy of the Aquilaria malaccensis leaves active fraction in glucose uptake in skeletal muscle on diabetic Wistar rats. IJHSR. 2016;6(7):162–7.Google Scholar
- Stajner D, Milic N, Mimica-dukic N, Lazic B, Igic R. Antioxidant abilities of cultivated and wild species of garlic. Phytother Res. 1998;12:513–4.Google Scholar
- Suhatri S, Putra DZ, Elisma E. Effect of aloe leaf extract (Aquilaria malaccensis Lamk.) on atherosclerosis in quail bull (Coturnix-coturnix japonica) (author’s transl). J Farmasi Higea. 2017;6:174–82.Google Scholar
- Sun J, Xia F, Wang S, Wang KY, Chen JM, Tu PF. Structural elucidation of two new megastigmane glycosides from the leaves of Aquilaria sinensis. Chin J Nat Med. 2015;13:0290–4.Google Scholar
- Vakati K, Rahman H, Eswaraiah MC, Dutta AM. Evaluation of hepatoprotective activity of ethanolic extract of Aquilaria agallocha leaves (EEAA) against CCl4 induced hepatic damage in rat. Sch J App Med Sci. 2013;1:9–12.Google Scholar
- Wang H. Determination of Genkwanin in the leaves of Aquilaria sinensis (Lour.) Gilg with HPLC. Guiding J Trad Chin Med Pharm. 2008;14:69–70.Google Scholar
- Zulkifle NL, Omar NAM, Tajuddin SN, Shaari MR. Anti-diabetic activities of Malaysian Agarwood (Aquilaria Spp.) Leaves extract conference on Industry–Academia joint initiatives in Biotechnology CIA. Biotech. 2013;13:5–7.Google Scholar