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Biomedical Application of Nanoparticles for Channel Protein Modulation to Control Neural Disorder with Special Reference to Seizure

  • Pankaj Kalita
  • Manash Barthakur
Chapter

Abstract

Channel proteins are the regulators of entry and exit of different molecules and ion to and fro from the cells. Regulation of entry and exit of molecules through different channel proteins can control different disorders. Therapeutic agents are used to target the channel protein to regulate ionic entry. Engineered channel proteins are developed to modify the channel protein movement. Epilepsy, which is marked by repeated seizures, is one of the serious neural disorder prevailing worldwide. Epileptic disorder is an electrophysiological alteration in the neuronal level and these electrophysiological changes are regulated by inward and outward movement of sodium, calcium, potassium, chloride ions, etc. Ions move through different channel proteins, and their movements are regulated by different channel proteins. These channel proteins are charge dependent and can be modulated by charged molecules. Nanoparticles are charged molecules and can be used to modulate channel proteins. Besides, nanoparticles have more exceptional properties than its raw materials which are helpful in the drug delivery approach. In the present article, it is targeted to focus and highlight the structural and functional approach of channel proteins and application of nanoparticles to control channel protein regulation which can help control different neural disorders including seizure.

Keywords

Channel protein Therapeutic agent Seizure Nanoparticle 

References

  1. 1.
    McCleskey EW, Fox AP, Feldman D, Tsien RW (1986) Different types of calcium channels. J Exp Biol 124:177–190PubMedGoogle Scholar
  2. 2.
    Zamponi GW, Striessnig J, Koschak A, Dolphin AC (2015) The physiology, pathology, and pharmacology of voltage-gated Calcium channels and their future therapeutic potential. Pharmacol Rev 67:821–870CrossRefGoogle Scholar
  3. 3.
    Zhu MX, Evans AM, Ma J, Parrington J, Galione A (2010) Two-pore channels for integrative Ca signaling. Commun Integr Biol 3(1):12–17CrossRefGoogle Scholar
  4. 4.
    Izumi Y, Ishikawa M, Benz AM, Izumi M, Zorumski CF, Thio LL (2004) Acute vigabatrin retino-toxicity in albino rats depends on light but not GABA. Epilepsia 45(9):1043–1048CrossRefGoogle Scholar
  5. 5.
    Eisenberg MJ, Brox A, Alain N, Bestawros MD (2004) Calcium channel blockers: an update. Am J Med 116(1):35–43CrossRefGoogle Scholar
  6. 6.
    Barthakur M (2018) Impact of gold nanoparticles on electrophysiology and intracellular calcium in cultured neuronGoogle Scholar
  7. 7.
    Mout R, Moyano DF, Rana S, Rotello VM (2012) Surface functionalization of nanoparticles for nanomedicine. Chem Soc Rev 41(7):2539–2544.  https://doi.org/10.1039/c2cs15294kCrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Paviolo C, Stoddart PR (2017) Gold nanoparticles for modulating neuronal behavior. Nanomaterials (Basel) 7(4):92.  https://doi.org/10.3390/nano7040092CrossRefGoogle Scholar
  9. 9.
    Lovisolo D, Gilardino A, Ruffinatti FA (2014) When neurons encounter nanoobjects: spotlight on calcium signalling. Int J Environ Res Public Health 11(9):9621–9637.  https://doi.org/10.3390/ijerph110909621CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Pankaj Kalita
    • 1
  • Manash Barthakur
    • 2
  1. 1.Department of BiophysicsPub Kamrup CollegeBaihata Chariali, KamrupIndia
  2. 2.Department of ZoologyPub Kamrup CollegeBaihata Chariali, KamrupIndia

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