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Recent Advances in Phytochemicals and Their Synergistic Role in Multiple Myeloma

  • Sharmistha Singh
  • Astha Dwivedi
Chapter

Abstract

Multiple myeloma (MM) is a rarely seen hematological malignancy, which has been characterized by the malignant proliferation of monoclonal plasma cells. MM generates uncontrolled growth of monoclonal plasma cells in the bone marrow, leading to production of nonfunctional intact immunoglobulin or immunoglobulin chain. MM is associated with the addition of chromosome abnormalities, copy number abnormalities, genetic mutation, and gene expression signature. MM is incurable but highly treatable by several targeted drug therapy, these drug show synergistic beneficial effect with phytochemicals. Phytochemicals are natural compound inbuilt with anti –inflammatory and anti-cancer properties. Specific plants and there phytochemicals were investigated and processed for their anti – inflammatory and anti-cancerous properties. Phytochemicals has antioxidant and anti-inflammatory activity had found to be beneficial in suppression of abnormal plasma cell growth. The aim of this review is to examine the synergistic pathways between phytochemicals and anti- cancer drug used in the treatment of multiple myeloma.

Keywords

Multiple myeloma Anticancer drugs Phytochemicals Plasma cells Anti-inflammatory 

References

  1. Adams J. The proteasome: a suitable anti neoplastic target. Nat Rev Cancer. 2004;4:349–60.CrossRefGoogle Scholar
  2. Aggarwal BB, Kumar A, Aggarwal MS, et al. Curcumin derived from turmeric Curcuma longa: a spice for all seasons. In: Phytopharmaceuticals in cancer chemoprevention. Boca Raton: CRC Press; 2005. p. 349–87.Google Scholar
  3. Amantini C, Ballarini P, Caprodossi S, et al. Triggering of transient receptor potential type 1 (TRPV1) by capsaicin induces FAS/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009;30:1320–9.CrossRefGoogle Scholar
  4. Anupama N, Madhumitha G, Rajesh KS. Role of dried fruits of Carissa carandas as anti-inflammatory agents and the analysis of phytochemical constituents by GC-MS. BioMed Res Int. 2014;2014:6.CrossRefGoogle Scholar
  5. Bley KB, Boorman G, Mohammad B, et al. Comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin. Toxicol Pathol. 2012;40:847–73.CrossRefGoogle Scholar
  6. Choi EJ, Kim T, Lee MS. Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer sk-ov-3 cells. Life Sci. 2007;80(15):1403–8.CrossRefGoogle Scholar
  7. Chung CS, Jiang Y, Cheng D, et al. Impact of adenomatous polyposis coli (APC) tumor suppressor gene in human colon cancer cell lines on cell cycle arrest by apigenin. Mol Carcinog. 2007;46(9):773–82.CrossRefGoogle Scholar
  8. Cragg GM, Newman DJ. Plants as a source of anticancer agents. J Ethnopharmacol. 2005;100:72–9.CrossRefGoogle Scholar
  9. Debes-Marun CS, Dewald GW, Bryant S, et al. Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia. 2003;17:427–36.CrossRefGoogle Scholar
  10. Dijsselbloem N, Vanden BW, De Naeyer A, et al. Soy isoflavonephyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy. Biochem Pharmacol. 2004;68(6):1171–85.CrossRefGoogle Scholar
  11. El-Alfy TS, Ezzat SM, Hegazy AK, et al. Isolation of biologically active constituents from Moringaperegrina (Forssk.) Fiori. (family: Moringaceae) growing in Egypt. Pharmacogn Mag. 2011;7(26):109–15.CrossRefGoogle Scholar
  12. Harrison AM, Thalji NM, Greenberg AJ, et al. Rituximab for non-Hodgkin’s lymphoma: a story of rapid success in translation. Clin Transl Sci. 2014;1:82–6.CrossRefGoogle Scholar
  13. Haywood, Good P, Khan S, et al. Corticosteroids for the management of cancer-related pain in adults. Cochrane Database Syst Rev. 2015;4:CD010756.Google Scholar
  14. Ito K, Nakazato T, Yamato K, et al. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res. 2004;64:1071–8.CrossRefGoogle Scholar
  15. Kyle RA, Therneau TM, Rajkumar SV, et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med. 2006;354:1362–9.CrossRefGoogle Scholar
  16. Landgren O, Kyle RA, Pfeifer RM, et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood. 2009;113:5412–7.CrossRefGoogle Scholar
  17. Langcake P, Pryce RJ. Production of resveratrol by vitis-vinifera and other members of vitaceae as a response to infection or injury. Physiol Plant Pathol. 1976;9:77–86.CrossRefGoogle Scholar
  18. Li Z, Yang Z, Peng X, et al. Nuclear factor-κB is involved in the protocadherin-10-mediated pro-apoptotic effect in multiple myeloma. Mol Med Rep. 2014;10:832–8.CrossRefGoogle Scholar
  19. Mahlberg Paul G, Soo Kim E. THC (tetrahyrdocannabinol) accumulation in glands of Cannabis (Cannabaceae). Hemp Rep. 2001;3:17.Google Scholar
  20. Manu KA, Kuttan G. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-B mediated activation of bcl-2 in B16F-10melanoma cells. Int Immunopharmacol. 2008;8:974–81.CrossRefGoogle Scholar
  21. Seidl S, Kaufmann H, Drach J. New insights into the pathophysiology of multiple myeloma. Lancet Oncol. 2003;4:557–64.CrossRefGoogle Scholar
  22. Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2008.Google Scholar
  23. Vargo MA, Voss OH, Poustka F. Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol. 2006;72:681–92.CrossRefGoogle Scholar
  24. Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer. 1999;35:1517–25.CrossRefGoogle Scholar
  25. Watt JM, Breyer BW, Gerdina M. The medicinal and poisonous plants of Southern and Eastern Africa. 2nd ed. Edinburgh: Oxford University Press; 1962.. Pub. E & S LivingstoneGoogle Scholar
  26. Wick W, Grimmel C, Wagenknecht B. Betulinic acid-induced apoptosis in glioma cells: a sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J Pharmacol Exp Ther. 1999;289:1306–12.PubMedGoogle Scholar
  27. Yang CS, Landau JM, Huang MT, et al. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr. 2001;21:381–406.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Sharmistha Singh
    • 1
  • Astha Dwivedi
    • 1
  1. 1.Department of Biochemistry, Faculty of ScienceUniversity of AllahabadAllahabadIndia

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