Recent Advances in Phytochemicals and Their Synergistic Role in Multiple Myeloma
Multiple myeloma (MM) is a rarely seen hematological malignancy, which has been characterized by the malignant proliferation of monoclonal plasma cells. MM generates uncontrolled growth of monoclonal plasma cells in the bone marrow, leading to production of nonfunctional intact immunoglobulin or immunoglobulin chain. MM is associated with the addition of chromosome abnormalities, copy number abnormalities, genetic mutation, and gene expression signature. MM is incurable but highly treatable by several targeted drug therapy, these drug show synergistic beneficial effect with phytochemicals. Phytochemicals are natural compound inbuilt with anti –inflammatory and anti-cancer properties. Specific plants and there phytochemicals were investigated and processed for their anti – inflammatory and anti-cancerous properties. Phytochemicals has antioxidant and anti-inflammatory activity had found to be beneficial in suppression of abnormal plasma cell growth. The aim of this review is to examine the synergistic pathways between phytochemicals and anti- cancer drug used in the treatment of multiple myeloma.
KeywordsMultiple myeloma Anticancer drugs Phytochemicals Plasma cells Anti-inflammatory
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