Reprogramming of Tumor Associated Immune Cells by Phytochemicals: In-vitro Approaches for Cancer Treatment
In recent years, phytochemicals have emerged as potential therapeutic agents against various diseases such as diabetes, microbial infections and cancer due to their minimum side effects and low cost. Plant-derived molecules improve disease conditions either directly or indirectly via targeting disease-causing factors or boosting the immune system. The immunomodulatory actions of phytochemicals play a vital role in the improvement of diabetes, microbial diseases, and cancer. Further, immunomodulatory properties of phytochemicals have been observed in tumor-bearing hosts. Therefore, phytochemicals with immunomodulatory properties are emerging as immunotherapeutic agents against cancer. The present book chapter discusses the in vitro immunomodulatory properties of phytochemicals against tumor-associated immune cells and associated mechanisms.
KeywordsCancer immunotherapy Immunomodulation Phytochemicals Tumor-associated immune cells
We thankfully acknowledge fellowship support to Pradip Kumar Jaiswara [Award No. 1002/(SC)(CSIR-UGC NET DEC. 2016] and Shiv Govind Rawat [Award No. 09/013(0772/2018-EMR-I)] from CSIR, New Delhi and Pratishtha Sonker [Award No. F117.1/201516/RGNF201517SCUTT4822/(SAIII/Website)] from UGC, New Delhi. Funding from University Grants Commission and Department of Science & Technology, New Delhi, India, in the form of UGC-Start-Up Research (F. No. 30-370/2017 (BSR)) and Early Career Research Award (ECR/2016/001117) is highly acknowledged. Financial support from ISLS and UGC-UPE, Banaras Hindu University is also acknowledged. We also acknowledge UGC-CAS and DST-FIST program to the Department of Zoology, Banaras Hindu University, India.
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