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Introduction: Sequence-Specific DNA Binding Pyrrole–Imidazole Polyamides and Their Applications

  • Yusuke KawamotoEmail author
Chapter
Part of the Springer Theses book series (Springer Theses)

Abstract

Pyrrole–imidazole polyamides (Py–Im polyamides) are cell-permeable compounds that bind to the minor groove of double-stranded DNA in a sequence-specific manner without causing denaturation of the DNA. These compounds can be used to control gene expression and to stain specific sequences in cells. Here, we review the history, structural variations, and functional investigations of Py–Im polyamides.

Keywords

DNA binding molecules Pyrrole–imidazole polyamides Minor groove binder Gene regulation Cellular imaging 

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of CaliforniaSan Diego, La JollaUSA

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