Overview of Neuroimmunology

  • Heng Liu
  • Li Li
  • Hongjun Li


Patients with neuroimmunological syndromes pose many clinical challenges for the attending physician. Even experienced clinicians occasionally arrive at the point where diagnostic, work-up, treatment, or prognosis becomes blocked.


Neuroimmunological syndromes Multiple sclerosis Granulomatous diseases Autoimmune encephalitis 


  1. 1.
    Mix E, Goertsches R, Zettl UK. Immunology and neurology. J Neurol. 2007;254(2):II2–7.PubMedGoogle Scholar
  2. 2.
    Gao B, Zee CS. Neuroinfection & neuroimmunology: new opportunities, new challenges. Radiol Infect Dis. 2016;3:51–3.Google Scholar
  3. 3.
    Watkins SC, Salter RD. Functional connectivity between immune cells mediated by tunneling nanotubules. Immunity. 2005;23(3):309–18.PubMedGoogle Scholar
  4. 4.
    Dustin ML, Colman DR. Neural and immunological synaptic relations. Science. 2002;298(5594):785–9.PubMedGoogle Scholar
  5. 5.
    Hoftberger R. Neuroimmunology: an expanding frontier in autoimmunity. Front Immunol. 2015;6:206.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Rustom A, Saffrich R, Markovic I, et al. Nanotubular highways for intercellular organelle transport. Science. 2004;303(5660):1007–10.PubMedGoogle Scholar
  7. 7.
    Goldenberg MM. Multiple sclerosis review. Pharm Ther. 2012;37(3):175.Google Scholar
  8. 8.
    Hagens M, van Berckel B, Barkhof F. Novel MRI and PET markers of neuroinflammation in multiple sclerosis. Curr Opin Neurol. 2016;29(3):229–36.PubMedGoogle Scholar
  9. 9.
    Tomassini V, d’Ambrosio A, Petsas N, et al. The effect of inflammation and its reduction on brain plasticity in multiple sclerosis: MRI evidence. Hum Brain Mapp. 2016;37(7):2431–45.PubMedPubMedCentralGoogle Scholar
  10. 10.
    Barkhof F, Filippi M, Miller DH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain. 1997;120(11):2059–69.PubMedGoogle Scholar
  11. 11.
    Werring D, Clark C, Barker G, et al. Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology. 1999;52(8):1626–32.PubMedGoogle Scholar
  12. 12.
    Rawat A, Bhattad S, Singh S. Chronic granulomatous disease. Indian J Pediatr. 2016;83(4):345–53.PubMedGoogle Scholar
  13. 13.
    Roxo-Junior P, Simão HML. Chronic granulomatous disease: why an inflammatory disease? Braz J Med Biol Res. 2014;47(11):924–8.PubMedPubMedCentralGoogle Scholar
  14. 14.
    Wu U-I, Holland SM. A genetic perspective on granulomatous diseases with an emphasis on mycobacterial infections. Semin Immunopathol. 2016;38:199–212. Springer.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Razeka AAKA. Imaging appearance of granulomatous lesions of head and neck. Eur J Radiol. 2010;76(1):52–60.Google Scholar
  16. 16.
    Roos D. Chronic granulomatous disease. Br Med Bull. 2016;118:50.PubMedPubMedCentralGoogle Scholar
  17. 17.
    Isaac NM. In: Henderson RW, editor. Granulomatous diseases. PET-CT. New York: Springer; 2016. p. 289–306.Google Scholar
  18. 18.
    Armangue T, Leypoldt F, Dalmau J. Auto-immune encephalitis as differential diagnosis of infectious encephalitis. Curr Opin Neurol. 2014;27(3):361–8.PubMedPubMedCentralGoogle Scholar
  19. 19.
    Dalmau J, Rosenfeld MR. Autoimmune encephalitis update. Neuro-Oncology. 2014;16(6):771–8.PubMedPubMedCentralGoogle Scholar
  20. 20.
    Armangue T, Petitpedrol M, Dalmau J. Autoimmune encephalitis in children. J Child Neurol. 2012;27(11):1417–21.Google Scholar
  21. 21.
    Guan HZ, Ren HT, Cui LY. Autoimmune encephalitis: an expanding frontier of neuroimmunology. Chin Med J. 2016;129(9):1122–7.PubMedPubMedCentralGoogle Scholar
  22. 22.
    Leypoldt F, Armangue T, Dalmau J. Autoimmune encephalopathies. Ann N Y Acad Sci. 2010;85(10):94–114.Google Scholar
  23. 23.
    Graus F, Titulaer MJ, Balu R, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016;15(4):391–404.PubMedPubMedCentralGoogle Scholar
  24. 24.
    Deramecourt V, Bombois S, Debette S, et al. Bilateral temporal glioma presenting as a paraneoplastic limbic encephalitis with pure cognitive impairment. Neurologist. 2009;15(4):208–11.PubMedGoogle Scholar
  25. 25.
    Aupy J, Collongues N, Blanc F, et al. [Autoimmune encephalitis, clinical, radiological and immunological data]. Rev Neurol. 2013;169(2):142–53.Google Scholar
  26. 26.
    Lancaster E. The diagnosis and treatment of autoimmune encephalitis. J Clin Neurol. 2016;12(1):1–13.PubMedGoogle Scholar
  27. 27.
    Baumgartner A, Rauer S, Mader I, et al. Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody types. J Neurol. 2013;260(11):2744–53.PubMedGoogle Scholar
  28. 28.
    Rohde S. Inflammatory diseases of the meninges. Berlin: Springer; 2012.Google Scholar
  29. 29.
    Dalmau J, Graus F, Villarejo A, et al. Clinical analysis of anti-Ma2-associated encephalitis. Brain. 2004;127(Pt 8):1831–44.PubMedGoogle Scholar
  30. 30.
    Schär M, Wiesmann E. [Inflammatory diseases of the meninges. Epidemiology and examination methods]. Bibl Tuberc. 1967;23:1–11.Google Scholar
  31. 31.
    Fowler MI, Weller RO, Heckels JE, et al. Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges. Cell Microbiol. 2004;6(6):555–67.PubMedGoogle Scholar
  32. 32.
    Jan W, Zimmerman RA, Bilaniuk LT, et al. Diffusion-weighted imaging in acute bacterial meningitis in infancy. Neuroradiology. 2003;45(9):634–9.PubMedGoogle Scholar
  33. 33.
    Andronikou S, Smith B, Hatherhill M, et al. Definitive neuroradiological diagnostic features of tuberculous meningitis in children. Pediatr Radiol. 2004;34(11):876–85.PubMedGoogle Scholar
  34. 34.
    Garg RK, Malhotra HS, Jain A. Neuroimaging in tuberculous meningitis. Neurol India. 2016;64(2):219–27.PubMedGoogle Scholar
  35. 35.
    Manelfe C, Sarrazin JL. Spinal cord inflammatory and demyelinating diseases. In: Diseases of the brain head & neck spine. Milan Berlin Heidelberg, New York: Springer; p. 195–9.Google Scholar
  36. 36.
    Demaerel P, Ross JS. Spinal cord inflammatory and demyelinating diseases. Cham: Springer; 2016.Google Scholar
  37. 37.
    Castillo M, Tortori-Donati P. Infectious and inflammatory disorders of the spine. Berlin: Springer; 2005.Google Scholar
  38. 38.
    Stoll G, Bendszus M, Perez J, et al. Magnetic resonance imaging of the peripheral nervous system. Phys Med Rehabil Clin N Am. 2001;12(2):399–432.Google Scholar
  39. 39.
    Judmaier W. Introduction to magnetic resonance imaging of the peripheral nervous system: general considerations and examination technique. Berlin: Springer; 2013.Google Scholar
  40. 40.
    Markvardsen LH, Vaeggemose M, Ringgaard S, et al. Diffusion tensor imaging can be used to detect lesions in peripheral nerves in patients with chronic inflammatory demyelinating polyneuropathy treated with subcutaneous immunoglobulin. Neuroradiology. 2016;58(8):745–52.PubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Heng Liu
    • 1
  • Li Li
    • 2
  • Hongjun Li
    • 2
  1. 1.Department of RadiologyAffiliated Hospital of Zunyi Medical UniversityZunyiChina
  2. 2.Department of Radiology, Beijing You’an HospitalCapital Medical UniversityBeijingChina

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