Breadfruit Peel Extract Impact on HeLa Cancer Cell Viability and Proliferation

  • Suhassni GanesonEmail author
  • Muhammad Mahadi bin Abdul Jamil
  • Radzi bin Ambar
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 547)


Cancer is referred to a type of diseases characterized by an abnormal growth of cells in bodies, and it’s the second leading cause of death worldwide. While numerous treatments associated with cancer therapy being practise, it also said to have serious permanent side effects due to high usage of drugs in the treatment. Said that, a fine complementary method which can eliminate the side effect of drugs is needed. Constituents obtained from plant extract have been a potent source of anti-cancer agents. This present review is mainly to emphasize potentiality of artocarpus altilis (peel part) in opposing the proliferation of cervical cancer cell over a period of 72 h. Proliferation factor and viability of cervical cancer cell observed with different concentration of peel part of artocarpus altilis ranging from control, 10, 20, 30, 40, and 50 µg/ml. Result obtained from this research shows decrease in percentage of cervical cancer cell viability as well as cell proliferation rate with the increase of extract concentration. Thus the study result quantitatively proves the dependence of cell proliferation on extract concentration. Findings of this study can be applied in electrochemotherapy field as Artocarpus altilis/breadfruit has the ability to inhibit cervical cancer cell proliferation and viability.


Artocarpus altilis Cervical cancer cell Cell viability Cell proliferation Cancer Anti-cancer agent 



The author would like to thank the supervisor Associate Professor Dr. Muhammad Mahadi bin Abdul Jamil for the guidance support. Author would like to acknowledge the financial support of Ministry of Education Malaysia through MyMasters (MyBrain15). This work was sponsored by Universiti Tun Hussein Onn Malaysia (UTHM) through grant contract project VOT no. U551, VOT no. U775 and Kementerian pengajian Tinggi (KPT).


  1. 1.
    Cervical Cancer Estimated Incidence, Mortality and Prevalence Worldwide in 2012. World Health Organization (WHO) (2015)Google Scholar
  2. 2.
    Types of Cancer Treatment. National Cancer Institute (2017)Google Scholar
  3. 3.
    Chemotherapy for Testicular Cancer—American Cancer Society (2016)Google Scholar
  4. 4.
    Mohanty, M., Pradhan, C.: A review on phytochemistry, bio-efficacy, medicinal and ethno-pharmaceutical importance of Artocarpus altilis. Int. J. Pharm. Pharm. Res. (2015)Google Scholar
  5. 5.
    Somashekar, M., Nayeem, N., Sonnad, B.: A review on family Moraceae (Mulberry) with a focus on Artocarpus species. World J. Pharm. Pharm. Sci. (2013)Google Scholar
  6. 6.
    Pradhan, C., Mohanty, M., Rout, A.: Phytochemical screening and comparative bioefficacy assessment of Artocarpus altilis leaf extracts for antimicrobial activity. Front. Life Sci. (2013)Google Scholar
  7. 7.
    Ragone, D.: Breadfruit: Artocarpus altilis (Parkinson) Fosberg—Promoting The Conservation and Use of Underutilized and Neglected Crops (1997)Google Scholar
  8. 8.
    Arung, E.T., Wicaksono, B.D., Handoko, Y.A., Kusuma, I.W., Yulia, D., Sandra, F.: Anti-cancer properties of diethylether extract of wood from sukun (Artocarpus altilis) in human breast cancer (T47D) Cells. Trop. J. Pharm. Res. August (2009)Google Scholar
  9. 9.
    Tian, Q., Zang, Y.H.: Antiproliferative and apoptotic effects of the ethanolic herbal extract of Achillea falcata in human cervical cancer cells are mediated via cell cycle arrest and mitochondrial membrane potential loss. US National Library of Medicine National Institutes of Health (2015)Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Suhassni Ganeson
    • 1
    Email author
  • Muhammad Mahadi bin Abdul Jamil
    • 1
  • Radzi bin Ambar
    • 2
  1. 1.Faculty of Electrical and Electronics Engineering, Biomedical Modelling and Simulation (BIOMEMS) Research GroupUniversiti Tun Hussein Onn MalaysiaParit RajaMalaysia
  2. 2.Faculty of Electrical and Electronics Engineering, Embedded Computing Systems (EmbCoS) Focus GroupUniversiti Tun Hussein Onn MalaysiaParit RajaMalaysia

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