Cardiopulmonary and Gastrointestinal Manifestations of Patients with Ankylosing Spondylitis

  • Jun Fu
  • Zheng Wang


Many previous publications have reported that cardiac manifestations were involved in 2–10% of AS patients, such as aortitis, cardiomyopathy, conduction disorders, and valvular regurgitation, and were associated with AS. What is more, human leukocyte antigen (HLA)-B27 is found in most AS patients and is demonstrated to contribute to the pathophysiologic changes of the aforementioned conditions [1].


  1. 1.
    Moyssakis I, Gialafos E, Vassiliou VA, et al. Myocardial performance and aortic elasticity are impaired in patients with ankylosing spondylitis. Scand J Rheumatol. 2009;38(3):216–21.CrossRefPubMedGoogle Scholar
  2. 2.
    Bulkley BH, Roberts WC. Ankylosing spondylitis and aortic regurgitation: description of the characteristic cardiovascular lesion from study of eight necropsy patients. Circulation. 1973;48(5):1014–27.CrossRefPubMedGoogle Scholar
  3. 3.
    Roldan CA, Chavez J, Wiest PW, et al. Aortic root disease and valve disease associated with ankylosing spondylitis. J Am Coll Cardiol. 1998;32(5):1397–404.CrossRefPubMedGoogle Scholar
  4. 4.
    Kaźmierczak J, Peregud-Pogorzelska M, Biernawska J, et al. Cardiac arrhythmias and conduction disturbances in patients with ankylosing spondylitis. Angiology. 2008;58(6):751–6.CrossRefGoogle Scholar
  5. 5.
    Toussirot E, Bahjaoui-Bouhaddi M, Poncet JC, et al. Abnormal autonomic cardiovascular control in ankylosing spondylitis. Ann Rheum Dis. 1999;58(8):481–7.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Fu J, Wu MY, Liang Y, et al. Differences in cardiovascular manifestations between ankylosing spondylitis patients with and without kyphosis. Clin Rheumatol. 2016;35(8):2003–8.CrossRefPubMedGoogle Scholar
  7. 7.
    Fu J, Song K, Zhang YG, et al. Changes in cardiac function after pedicle subtraction osteotomy in patients with a kyphosis due to ankylosing spondylitis. Bone Joint J. 2015;97-B(10):1405–10.CrossRefPubMedGoogle Scholar
  8. 8.
    Dunham C, Kautz F. Sondylarthritis ankylopoietica, a review and report of twenty cases. Am J Med Sci. 1941;201:232–50.CrossRefGoogle Scholar
  9. 9.
    Kanathur N, Lee-Chiong T. Pulmonary manifestations of ankylosing spondylitis. Clin Chest Med. 2010;31(3):547–54.CrossRefPubMedGoogle Scholar
  10. 10.
    Davies D. Lung fibrosis in ankylosing spondylitis. Thorax. 1972;27(2):262.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Thai D, Ratani RS, Salama S, Steiner RM. Upper lobe fibrocavitary disease in a patient with back pain and stiffness. Chest. 2000;118(6):1814–6.CrossRefPubMedGoogle Scholar
  12. 12.
    Baser S, Cubukcu S, Ozkurt S, et al. Pulmonary involvement starts in early stage ankylosing spondylitis. Scand J Rheumatol. 2006;35(4):325–7.CrossRefPubMedGoogle Scholar
  13. 13.
    Casserly IP, Fenlon HM, Breatnach E, Sant SM. Lung findings on high-resolution computed tomography in idiopathic ankylosing spondylitis-correlation with clinical findings, pulmonary function testing and plain radiography. Br J Rheumatol. 1997;36(6):677–82.CrossRefPubMedGoogle Scholar
  14. 14.
    Souza AS, Müller NL, Marchiori E, et al. Pulmonary abnormalities in ankylosing spondylitis: inspiratory and expiratory high-resolution CT findings in 17 patients. J Thorac Imaging. 2004;19(4):259–63.CrossRefPubMedGoogle Scholar
  15. 15.
    Senocak O, Manisali M, Ozaksoy D, et al. Lung parenchyma changes in ankylosing spondylitis: demonstration with high resolution CT and correlation with disease duration. Eur J Radiol. 2003;45:117–22.CrossRefPubMedGoogle Scholar
  16. 16.
    Zhang GY, Fu J, Zhang YG, et al. Lung volume change after pedicle subtraction osteotomy in patients with ankylosing spondylitis with thoracolumbar kyphosis. Spine (Phila Pa 1976). 2015;40(4):233–7.CrossRefGoogle Scholar
  17. 17.
    Fu J, Zhang GY, Zhang YG, et al. Pulmonary function improvement in patients with ankylosing spondylitis kyphosis following pedicle subtraction osteotomy. Spine (Phila Pa 1976). 2014;39(18):E1116–22.CrossRefGoogle Scholar
  18. 18.
    de Vlam K, Mielants H, Cuvelier C, et al. Spondyloarthropathy is underestimated in inflammatory bowel disease: prevalence and HLA association. J Rheumatol. 2000;27:2860–5.PubMedGoogle Scholar
  19. 19.
    Brophy S, Pavy S, Lewis P, et al. Inflammatory eye, skin, and bowel disease in spondyloarthritis: genetic, phenotypic, and environmental factors. J Rheumatol. 2001;28:2667–73.PubMedGoogle Scholar
  20. 20.
    Smale S, Natt RS, Orchard TR, et al. Inflammatory bowel disease and spondylarthropathy. Arthritis Rheum. 2001;44:2728–36.CrossRefPubMedGoogle Scholar
  21. 21.
    Vaile JH, Meddings JB, Yacyshyn BR, et al. Bowel permeability and CD45RO expression on circulating CD20CB cells in patients with ankylosing spondylitis and their relatives. J Rheumatol. 1999;26:128–35.PubMedGoogle Scholar
  22. 22.
    Liu C, Song K, Zhang YG, et al. Changes of the abdomen in patients with ankylosing spondylitis kyphosis. Spine. 2014;40:E43–8.CrossRefGoogle Scholar
  23. 23.
    Liu C, Zheng GQ, Zhang YG, et al. The radiologic, clinical results and digestive function improvement in patients with ankylosing spondylitis kyphosis after pedicle subtraction osteotomy. Spine J. 2015;15:1988–93.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jun Fu
    • 1
  • Zheng Wang
    • 1
  1. 1.Chinese PLA General HospitalBeijingChina

Personalised recommendations