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L-Ergothioneine: A Potential Bioactive Compound from Edible Mushrooms

  • Saraswathy NachimuthuEmail author
  • Ruckmani Kandasamy
  • Ramalingam Ponnusamy
  • Jack Deruiter
  • Muralikrishnan Dhanasekaran
  • Sivasudha Thilagar
Chapter

Abstract

Edible mushrooms possess health-promoting bioactive compounds and are used throughout the world for their extensive medicinal properties. One of the unique bioactive compounds found in mushrooms is the water-soluble thiol-containing antioxidant amino acid, L-ergothioneine (LE). It is a stable antioxidant molecule and does not degrade at high temperature and high pH. L-Ergothioneine is not synthesized by plants and animals, including human. Therefore, LE is obtained through dietary sources, mainly from edible mushrooms such as Agaricus bisporus, Lentinula edodes, Pleurotus ostreatus and Grifola frondosa. These mushroom species have been reported to have a high LE content in them. LE is considered as a molecule for longevity and referred to as longevity vitamin. In this chapter, we have described the sources, the cytoprotective mechanisms, and therapeutic potential of LE.

Keywords

Anti-inflammatory Antioxidant Cytoprotectant Health supplement L-Ergothioneine 

Abbreviations

ASF

Amphiphilic solute facilitator

ARE

Antioxidant response elements

ESSE

Ergothioneine disulfide

EFSA

European Food Safety Authority

8-BrdG

8-Bromo-2′-dG

ETT

Ergothioneine transporter

FDA

Food and Drug Administration

GRAS

Generally recognized as safe

GSH

Glutathione

HA

Hyaluronic acid

HPLC

High-performance liquid chromatography

HILIC

Hydrophilic interaction chromatography

HOBr

Hypobromous acid

HOCL

Hypochlorous

IL-6

Interleukin-6

LC-MS

Liquid chromatography-mass spectrometry

LE

L-Ergothioneine

MMP1

Matrix metalloproteinase 1

MPO

Myeloperoxidase

ND

Neurodegenerative diseases

OCTN1

Organic cation transporter

PLP

Pyridoxal 5-phosphate

ROS

Reactive oxygen species

RNS

Reactive nitrogen species

RT-PCR

Reverse transcription polymerase chain reaction

SAM

S-Adenosylmethionine

TNFα

Tumor necrosis factor alpha

UV

Ultraviolet

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Saraswathy Nachimuthu
    • 1
    Email author
  • Ruckmani Kandasamy
    • 2
  • Ramalingam Ponnusamy
    • 1
  • Jack Deruiter
    • 3
  • Muralikrishnan Dhanasekaran
    • 3
  • Sivasudha Thilagar
    • 4
  1. 1.Department of BiotechnologyKumaraguru College of TechnologyCoimbatoreIndia
  2. 2.Department of Pharmaceutical Technology, University College of Engineering, Bharathidasan Institute of Technology CampusAnna UniversityTiruchirappalliIndia
  3. 3.Department of Drug Discovery and Development, Harrison School of PharmacyAuburn UniversityAuburnUSA
  4. 4.Department of Environmental Biotechnology, School of Environmental SciencesBharathidasan UniversityTiruchirappalliIndia

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