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Screening of Drugs Using Cell Lines/Isolated Tissues/Intact Animals

  • Jayanta Kumar Patra
  • Swagat Kumar Das
  • Gitishree Das
  • Hrudayanath Thatoi
Chapter
Part of the Learning Materials in Biosciences book series (LMB)

Abstract

Animal models have been extensively used for pharmaceutical evaluations of antidiabetic drugs and active principles of plant extracts for evaluation of their potency, mechanism of action and possible side effects if any. However, no animal model is good enough to represent entirely the manifestations and characteristic feature of particular type diabetes as the pathogenesis of diabetes may show heterogeneous expressions in man. Hence, several animal models have been used in antidiabetic studies, each displaying a different set of features as per the condition observed in human diabetic conditions. Amongst the different models used, small rodents are the widely used animal models as they are comparatively inexpensive to maintain. Further, they also show a rapid onset of diabetes when experimentally induced which is usually consistent with their shorter lifespan.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Jayanta Kumar Patra
    • 1
  • Swagat Kumar Das
    • 2
  • Gitishree Das
    • 3
  • Hrudayanath Thatoi
    • 4
  1. 1.Research Institute of Biotechnology & Medical Converged ScienceDongguk UniversityGoyang-siSouth Korea
  2. 2.Department of BiotechnologyCollege of Engineering and Technology, Biju Patnaik University of TechnologyOdishaIndia
  3. 3.Dongguk UniversityGoyang-siSouth Korea
  4. 4.Department of BiotechnologyNorth Orissa UniversityOdishaIndia

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