Mitochondrial Aldehyde Dehydrogenase in Myocardial Ischemic and Ischemia-Reperfusion Injury

  • Jie Ding
  • Zheng Yang
  • Heng MaEmail author
  • Hao Zhang
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1193)


Myocardial ischemia-reperfusion (IR) injury during acute myocardial infarction or open-heart surgery would promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage. It has been well demonstrated that aldehyde dehydrogenase (ALDH)-2 is an important cardioprotective enzyme for its central role in the detoxification of reactive aldehydes. ALDH2 activation by small molecule activators is a promising approach for cardioprotection for myocardial IR injury.


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Cardiovascular Disease, Anesthesia Department, Fuwai Hospital, National Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina
  2. 2.Department of Physiology and PathophysiologyFourth Military Medical UniversityXi’anChina
  3. 3.Heart Center and Shanghai Institution of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, National Children’s Medical Center, Shanghai Jiaotong University School of MedlineShanghaiChina

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