A Side-Polished Fluorescent Fiber Sensor for the Detection of Blood in the Saliva
Laboratory analyses of body fluids for the determination of disease-signaling biomarkers is an important stage of the diagnostics procedure. Although blood is recognized to provide the most reliable diagnostics data, blood collection is an invasive procedure and is perceived with reluctance by many patients. Therefore, the presence of disease-signaling biomarkers in other body fluids is investigated. This paper proposes the block diagram of a hybrid salivary sensor which correlates optoelectronic sensing with electrochemical sensing. Saliva is indeed a preferred body fluid for sampling, however it may also contain other compounds, as for example oropharyngeal mucosae, blood, etc. In the context of the hybrid salivary sensor, this paper investigates two solutions for the implementation of an optical salivary sensor for the identification of blood in the saliva. In the proposed solutions, blood is identified by color, rather than by chemistry. Therefore, pure optical means can be used, making the implementation in the shape of a side polished fiber straightforward. The novelty of this work consists in the employment of a fluorescent optical fiber for the construction of the fiber optic sensor. A laboratory proof of principle validates the proposed solutions.
KeywordsSalivary sensor Blood identification Fluorescent optical fiber Side-polished optical fiber sensor
This study was supported by “Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Ph.D. Grant no 3999/01.10.2016, and partially by the COFUND-ERA-HDHL ERANET Project, European and International Cooperation—Subprogram 3.2—Horizon 2020, PNCDI III Program—Biomarkers for Nutrition and Health—“Innovative technological approaches for validation of salivary AGEs as novel biomarkers in evaluation of risk factors in diet-related diseases”, no 25/1.09.2017.
Conflict of Interest
The authors declare that they have no conflict of interest.
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