Hair Cell Regeneration

  • Yan Chen
  • Shasha Zhang
  • Renjie Chai
  • Huawei LiEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1130)


Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss. Many regulatory factors, including signaling pathways, transcription factors, and epigenetic regulators, play roles in hair cell regeneration in various species. In this chapter, we review the history of hair cell regeneration research, the methods used in the study of hair cell regeneration, the properties and modulating factors of inner ear stem cells, and the re-formation of cochlear ribbon synapses and hearing function recovery.


Auditory system Cochlea Hair cell regeneration Transcription factors Signaling pathways Epigenetic regulation 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Yan Chen
    • 1
    • 2
  • Shasha Zhang
    • 3
  • Renjie Chai
    • 4
    • 5
  • Huawei Li
    • 5
    Email author
  1. 1.ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT HospitalFudan UniversityShanghaiChina
  2. 2.NHC Key Laboratory of Hearing Medicine (Fudan University)Shanghai Engineering Research Centre of Cochlear ImplantShanghaiChina
  3. 3.Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Institute of Life SciencesSoutheast UniversityNanjingChina
  4. 4.MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjingChina
  5. 5.Key Laboratory of Hearing Medicine of NHFPC, ENT Institute and Otorhinolaryngology Department, Shanghai Engineering Research Centre of Cochlear Implant, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

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