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Molecular Diagnostics in Non-Hodgkin Lymphoma

  • Suraj PratapEmail author
  • Teresa A. Scordino
Chapter

Abstract

Non-Hodgkin Lymphomas (NHLs) are a diverse collection of malignant neoplasms of lymphoid cell origin which include all the malignant lymphomas that are not classified as Hodgkin lymphoma. NHL is the sixth most common type of cancer diagnosed in men and women in the United Kingdom. In the United States of America the past four decades have seen nearly an 80% rise in the incidence of NHL, one of the largest increases observed among any cancer. With improved understanding of biology, data from sequential disease-based clinical trials as well as better supportive care, the outcome of NHL has improved dramatically over the last several decades. Using conventional therapy, depending on subtype and stage, the majority of young adults with NHL can be cured. New insights into the molecular pathogenesis of NHL combined with recent headways in molecular biology and genetics have led to the discovery of several oncogenic pathways involved in lymphomagenesis, which in turn has augmented the diagnostic and therapeutic approaches for NHL patients. This review describes the presentation and evaluation of NHL and summarizes the current concepts about molecular diagnostics of the common subtypes.

Notes

Disclosure

The authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Jimmy Everest Section of Pediatric Hematology-OncologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  2. 2.Department of PathologyUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA

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