Molecular Diagnostics in Liver Cancer

  • Anil Kumar Chauhan
  • Monika Bhardwaj
  • Pankaj Kumar ChaturvediEmail author


Hepatocellular carcinoma (HCC or liver cancer) is emerging as the most common cancer with a conspicuous rate of mortality worldwide. The survival rate of liver cancer patients is as less as 6 months with a maximum of 2 years. Though there are various factors that cause the liver cancer, alcohol consumption and infection of hepatitis B and C are considered to be the most influential factors that contribute to the development of liver cancer. Moreover, treatment strategies are very limited due to poor diagnosis as it remains in the form of cirrhosis until it reaches to the advanced stage of carcinoma. On the other hand, transplantation of the liver is the only therapy which has shown the promising results in the patients with advanced liver cancer. However, there are numbers of research and clinical trials going on to develop some therapeutic candidate to combat this deadly disease. Moreover, there is a need to be subtler in the development of diagnostic markers specifically molecular mechanism involved in liver carcinogenesis which in turn could be used as therapeutic targets as well. The present chapter summarizes the work that has been done and is needed to improve or develop the molecular diagnosis of liver cancer.


Hepatocellular carcinoma Molecular diagnosis Nonalcoholic fatty liver disease 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Anil Kumar Chauhan
    • 1
  • Monika Bhardwaj
    • 1
  • Pankaj Kumar Chaturvedi
    • 2
    Email author
  1. 1.Laboratory of Biochemistry and Cellular EngineeringDaegu Gyeongbuk Institute of Science and TechnologyDaeguRepublic of Korea
  2. 2.Department of Radiation OncologyChungbuk National University HospitalCheongjuRepublic of Korea

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