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Absorption, Metabolism, and Disposition of Flavonoids and Their Role in the Prevention of Distinctive Cancer Types

  • Siddhi Bagwe-Parab
  • Ginpreet Kaur
  • Harpal Singh Buttar
  • Hardeep Singh Tuli
Chapter

Abstract

Flavonoids consist of a large family of polyphenolic molecules like flavones, flavonols, flavanols, isoflavones, flavanones, and anthocyanidins which are ubiquitously distributed in nature and are present in a wide array of plant products, including fruits, vegetables, and green tea. Because of their powerful antioxidant, anti-inflammatory, and anticancer properties, rigorous research is going on with a number of flavonoids (quercetin, quercitrin, rutin, morin, kaempferol, etc.) to investigate their disease-preventive and health-promoting benefits in humans. Several studies have shown that the cancer prevention and pharmacotherapeutic potential of different flavonoids depend on the type of flavonoid and its chemical structure, bioavailability, effective blood levels, and pharmacokinetic and pharmacodynamic characteristics. Many in vivo and in vitro studies conducted with different types of flavonoids have revealed diverse effects against different types of cancers. However, the major flavonoids (apigenin, luteolin, kaempferol) found in vegetarian diet have depicted limited possibility of curing cancer. In vitro studies done with apigenin and luteolin have shown effectiveness against cervical cancer cells, while kaempferol produced oncolytic effects against gastric and ovarian cancer cells. These flavonoids and their metabolites have revealed different anticancer effects due to their rapid metabolism in the small intestine and liver. Cancers comprise a group of noncommunicable diseases characterized by long-term debilitating illnesses that cause heavy burden on the healthcare system. At present, certain types of cancers are incurable, and palliative interventions are directed to delay the spread of malignant cancer and to ameliorate the painful episodes associated with cancer. The purpose of this review is to focus on the absorption, distribution, metabolism, and excretion (ADME) of different flavonoids and to evaluate the immune-boosting, cancer-preventive, and therapeutic potential of flavonoids against different types of cancers.

Keywords

Flavonoids Oxidative stress Antioxidant Anti-inflammation Anticancer Cancer prevention Chemoprotection ADME 

Notes

Conflict of Interest

The authors declare no conflict of interest.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Siddhi Bagwe-Parab
    • 1
  • Ginpreet Kaur
    • 1
  • Harpal Singh Buttar
    • 2
  • Hardeep Singh Tuli
    • 3
  1. 1.Department of PharmacologySPP School of Pharmacy and Technology ManagementMumbaiIndia
  2. 2.Department of Pathology and Laboratory Medicine, Faculty of MedicineUniversity of OttawaOttawaCanada
  3. 3.Department of BiotechnologyMaharishi Markandeshwar (Deemed to be University)Mullana-AmbalaIndia

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