From Macroscopic to Microscopic: Experimental and Computational Methods to Investigate Bio-tribology
Tribology is an important factor (among other factors) during biological interactions of devices and tissues. The paper discusses how new computational and experimental methods can be used to understand and improve the design and development of medical devices at macro and micro scales to sustain life beyond 50 years. We have used pre-clinical experiments and computational methods to understand interactions between orthopaedic implants at the macro scale. The computational model has been validated with experiments. Now this computational model can predict damage in implants for different patients. One such application was successfully tried and tested in collaboration with University National Autonomous Mexico. This methodology can be used in future to design patient specific, affordable (using 3D printing) and robust implants which will be useful for developing countries like Vietnam, India and Mexico. Improvement of catheter designs is important to reduce damage to the internal tissues while being used for cardiovascular problems. We are developing new experimental techniques (in micro scale) that can be used to understand the interaction of cells with the catheter material. These will help reduce the hospital costs incurred during longer stay of the patients admitted for cardiovascular related problems.
KeywordsFriction Wear Patella femoral joint Endothelial cells Catheter
This research was supported by Engineering and Physical Sciences Research Council (grant number EP/R001766/1) as a part of ‘Friction: The Tribology Enigma’ (www.friction.org.uk), a collaborative Programme Grant between the universities of Leeds and Sheffield, Royal Academy of Engineering Newton Fund (grant number NRCP1617/6/181) between University of Sheffield and University National Autonomous Mexico, and Peter Jost Travel Award.
Dr Raman Maiti would also like to thank Institute of Medical and Biological Engineering, University of Leeds and DePuy Synthesis for the assistance offered while conducting experimental studies of artificial patella femoral joint replacements during his Ph.D.
Conflict of Interest The authors declare that they have no conflict of interest.
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