Super-resolution Microscopy

  • Xiangang LuoEmail author


Optical microscopy is one of the most important scientific instruments in the history of mankind. It has revolutionized the field of life sciences and remains indispensable in many areas of scientific research. However, the resolution of the optical microscopy could not be enhanced infinitely through improving the amplification factor and eliminating the aberration due to the optical diffraction from a limited aperture in optical imaging system, and there exists a theoretical limit, which is named as diffraction limit. Essentially, this is attributed to the loss of high spatial frequencies that contain the details of an object. Although spatial or temporal manipulation of fluorescence microscopy has been demonstrated as an avenue of super-resolution microscopy, they require special labeling of the samples. With the development of subwavelength structured materials, superlens- and hyperlens-based super-resolution microscopies have been proposed for both intensity- and phase-contrast imaging. Furthermore, inspired by the dielectric microsphere-based photonic nanojets and far-field super-oscillation phenomena, new super-resolution microscopies have also been proposed, forming one important research direction of EO 2.0.


Microscopy Super-resolution Superlens Hyperlens 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering, Institute of Optics and ElectronicsChinese Academy of SciencesChengduChina

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