Exploiting Polyhydroxyalkanoates for Tissue Engineering

  • Subhasree Ray
  • Sanjay K. S. Patel
  • Mamtesh Singh
  • Gajendra Pratap Singh
  • Vipin Chandra Kalia


Petroleum based synthetic plastics are an integral part of our daily life. However, their excessive usage has resulted in environmental pollution. The primary reason for this pollution is due to their non-biodegradable nature. On the other hand, polyhydroxyalkanoates (PHAs) are biodegradable polymers, which have been shown to be produced by a wide range of bacteria. The unique feature of this bioplastic production is that they can be produced from renewable substrate materials through a unique metabolic route. These PHAs have the potential to replace petroleum based synthetic plastics. PHAs have high commercial value which make them suitable agent for industrial and medical applications. Although simpler and monomeric forms of PHAs have limited biotechnological applications, however, modified forms of PHA can be used in various medical applications such as, drug delivery, biodegradable implants, anticancer agent, and tissue engineering etc. Among all, tissue engineering has emerged globally to improve the current therapeutic approaches, entailing a revolution in clinical practice. PHAs offer several benefits in tissue engineering. These chemically modified biopolymers can be used in tissue repair, regeneration of tissue, scaffolds preparation etc.


Polyhydroxyalkanoates Tissue engineering Biotechnology Bacteria Bacillus Copolymers 



This work was supported by Brain Pool grant (NRF-2018H1D3A2001746) by National Research Foundation of Korea (NRF) to work at Konkuk University.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Subhasree Ray
    • 1
    • 2
  • Sanjay K. S. Patel
    • 3
  • Mamtesh Singh
    • 4
  • Gajendra Pratap Singh
    • 5
  • Vipin Chandra Kalia
    • 3
  1. 1.Microbial Biotechnology and GenomicsCSIR – Institute of Genomics and Integrative Biology (IGIB)DelhiIndia
  2. 2.Academy of Scientific & Innovative Research (AcSIR)New DelhiIndia
  3. 3.Department of Chemical EngineeringKonkuk UniversitySeoulRepublic of Korea
  4. 4.Department of Zoology, Gargi CollegeUniversity of DelhiDelhiIndia
  5. 5.Mathematical Sciences and Interdisciplinary Research Lab (MathSciIntR-Lab), School of Computational and Integrative SciencesJawaharlal Nehru UniversityNew DelhiIndia

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