Skin Changes During Ageing

  • Frédéric Bonté
  • Dorothée Girard
  • Jean-Christophe Archambault
  • Alexis DesmoulièreEmail author
Part of the Subcellular Biochemistry book series (SCBI, volume 91)


The skin provides the primary protection for the body against external injuries and is essential in the maintenance of general homeostasis. During ageing, resident cells become senescent and the extracellular matrix, mainly in the dermis, is progressively damaged affecting the normal organization of the skin and its capacity for repair. In parallel, extrinsic factors such as ultraviolet irradiation, pollution, and intrinsic factors such as diabetes or vascular disease can further accelerate this phenomenon. Indeed, numerous mechanisms are involved in age-induced degradation of the skin and these also relate to non-healing or chronic wounds in the elderly. In particular, the generation of reactive oxygen species seems to play a major role in age-related skin modifications. Certainly, targeting both the hormonal status of the skin or its surface nutrition can slow down age-induced degradation of the skin and improve healing of skin damage in the elderly. Skin care regimens that prevent radiation and pollution damage, and reinforce the skin surface and its microbiota are among the different approaches able to minimize the effects of ageing on the skin.


Wound healing Myofibroblast Extracellular matrix Oestrogen Reactive oxygen species Pollution Microbiota 



adipose tissue-derived stem cell


advanced glycation end-products


adenosine monophosphate-activated protein kinase


activator protein-1


caloric restriction


connective tissue growth factor


dermal-epidermal junction


extracellular matrix


hydroxysteroid dehydrogenase




infrared radiation


methylene blue


matrix metalloproteinase


mesenchymal stem cell




platelet-derived growth factor


reactive oxygen species


superoxide dismutase


transforming growth factor-β1


tissue inhibitors of metalloproteinases


tumour necrosis factor-α




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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Frédéric Bonté
    • 1
  • Dorothée Girard
    • 2
    • 3
  • Jean-Christophe Archambault
    • 1
  • Alexis Desmoulière
    • 2
    Email author
  1. 1.LVMH RechercheSaint Jean de BrayeFrance
  2. 2.Faculties of Medicine and Pharmacy, Department of PhysiologyUniversity of Limoges, Myelin Maintenance and Peripheral Neuropathies (EA 6309)LimogesFrance
  3. 3.Institut de Recherche Biomédicale des Armées, INSERM UMRS-MD 1197Centre de Transfusion Sanguine des ArméesClamartFrance

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