Starch-Based DDSs with Physiological Interactions

  • Jin ChenEmail author
  • Ling Chen
  • Fengwei Xie
  • Xiaoxi Li


Drug delivery systems (DDSs) are designed to be able to precisely control the release rate and/or target drugs to specific body sites. However, the successful application of DDSs could be limited in the clinical application due to the complicated environment of the human body. This can be exampled by the short circulation time and low targeting efficiency of target-specific DDSs induced by the RES recognition, or low bioavailability of drugs caused by short residence time of transmucosal DDSs at the site of absorption. Regarding this, in this chapter, strategies to improve the performance and bioavailability of starch-based DDSs are discussed. Target-specific starch-based DDSs can be achieved by passive and active targeting. Another possible strategy is the physical targeting of drugs by external stimuli, such as magnetic field. Also, the role of starch and its derivatives in transmucosal DDSs to improve the bioavailability of drugs by interacting with the absorbing mucosa or prolonging the residence time of drugs in the absorbing tissues are highlighted.


Transmucosal starch-based drug delivery system Bioadhesion Widening tight junction effect Target-specific starch-based drug delivery system Blood hematocompatibility Passive targeting Active targeting External targeting 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, Ministry of Education Engineering Research Center of Starch and Protein ProcessingSouth China University of TechnologyGuangzhouChina
  2. 2.International Institute for Nanocomposites Manufacturing (IINM), WMGUniversity of WarwickCoventryUK

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