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Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation

  • Keiko AoshimaEmail author
  • Hyogo Horiguchi
Chapter
Part of the Current Topics in Environmental Health and Preventive Medicine book series (CTEHPM)

Abstract

In 1968, the Ministry of Health and Welfare acknowledged that itai-itai disease, which occurred frequently in the Jinzu River basin of Toyama Prefecture, was a pollution disease. This chapter explores three topics related to itai-itai disease that have not been examined before with the aim of extracting historical lessons for the cadmium (Cd) environmental pollution problem in Japan. The first topic deals with the progress made by Dr. Kinichi Yoshioka, who first reported Cd environmental contamination, and suggested that itai-itai disease could be caused by chronic Cd poisoning. This topic focuses on the significance of ecological and epidemiological studies concerned with the actual circumstances surrounding heavy metal pollution (mainly Cd), in particular, the exposure route to the local residents. The second topic introduces the decision made by the administrative official that summarizes the opinion of the Ministry of Health and Welfare that “itai-itai disease is a pollution disorder caused by chronic Cd poisoning.” This opinion became the starting point for government pollution countermeasures as well as its policy decision-making process and illustrates that Cd environmental pollution presented a critical problem to regulatory science. The third topic analyzes “Cadmium Studies in Japan: A Review” published in 1978 and “Interim Report Summary” published in 1989. The progress made and the challenges encountered by the “Itai-itai Disease and Chronic Cd Poisoning Study Group” are then summarized. Since 1969, this group has been commissioned by the Ministry of Health and Welfare or the Ministry of the Environment to conduct studies to determine the relation between itai-itai disease and Cd poisoning. In the present circumstances surrounding Cd exposure in Japan, the daily Cd intake from the diet of general residents has decreased from 31.1 μg in 1981 to 17.8 μg in 2015 (a reduction of over 30% in over 30 years). The reason for this was considered to be a decrease in the intake of rice, a staple Japanese food, and a reduction in the Cd concentration in rice due to improvements in rice cultivation methods.

Keywords

Cadmium Environmental pollution Itai-itai disease Regulatory science Daily intake in Japan 

References

  1. 1.
    Saito H, Aoshima K. Heavy metals & human body II - the impact of heavy metals on human body. In: Chino M, Saito H, editors. Heavy metals & biology. Tokyo: Hakuyusha Publishers, Ltd; 1988. p. 167–211.Google Scholar
  2. 2.
    Friberg L, Elinder CG, Kjellstrom T, Nordberg GF. Cadmium and health: a toxicological and epidemiological approach, vol. Vol 1, 2. Boca Raton: CRC Press; 1986.Google Scholar
  3. 3.
    Aoshima K, Iwata K, Kasuya M. Environmental exposure to cadmium and effects on human health. Prat 1. Renal tubular function in inhabitants of the cadmium-polluted Jinzu River basin in Toyama prefecture. Jpn J Hyg. 1988;43:853–63. (in Japanese with English abstract)CrossRefGoogle Scholar
  4. 4.
    Yoshioka K. Report of mineral hazard downstream of the Jinzu River and its tributaries─mineral hazard on agriculture and on human being (Itai-itai disease). 1961. (in Japanese). In: Yoshioka K, editor. Study of Itai-itai Disease. Yonago: Tatara Shoboh Publisher, Ltd; 1970. p. 5–95.Google Scholar
  5. 5.
    Ministry of Health and Welfare. Opinion of the Welfare Ministry with regard to itai-itai disease and its causes in Toyama Prefecture. Collection of Special Documents about the Pollution of Government Office. 1968;3:12–25. (in Japanese)Google Scholar
  6. 6.
    Yoshioka K. Study of Itai-itai Disease. Yonago: Tatara Shoboh Publisher, Ltd; 1970. p. 1–334. (in Japanese with English summary)Google Scholar
  7. 7.
    Aoshima K. Itai-itai disease: lessons from the investigations of environmental epidemiology conducted in the 1970’s, with special reference to the studies of the Toyama Institute of Health. Jpn J Hyg. 2017;72:149–58. (in Japanese with English abstract)CrossRefGoogle Scholar
  8. 8.
    Yoshioka K. Epidemiological study on relationship between itai-itai disease and mining nuisance. Yamaguchi Igaku. 1964;13:146–71. (in Japanese)Google Scholar
  9. 9.
    Hagino N, Yoshioka K. A study on the cause of itai-itai disease. J Jpn Orthop Assoc. 1961;35:812–5. (in Japanese)Google Scholar
  10. 10.
    Toyama Prefecture. Report of the Regional Special Disease Control Committee. 1967. (in Japanese)Google Scholar
  11. 11.
    Japan Public Health Association. Study on the Etiology of Itai-itai Disease with Special Reference to the Distribution and Origins of Heavy Metals, Especially Cadmium; 1968. p. 1–58. (in Japanese)Google Scholar
  12. 12.
    Hashimoto M. My personal history with environmental administration. Tokyo: Asahi Newspapers; 1988. p. 1–376. (in Japanese)Google Scholar
  13. 13.
    Environmental Risk Subcommittee, a joint venture by Health & Life Science Committee and Environmental Studies Committee, Science Council of Japan. The State of Regulatory Science on Decision Making in Environmental Administration (Report); 2017. p. 1–24. (in Japanese)Google Scholar
  14. 14.
    Tsuchiya K. Cadmium studies in Japan: a review. New York: Kodansha; 1978. p. 1–376.Google Scholar
  15. 15.
    Japan Public Health Association Cadmium Research Committee. Interim summary report on studies of health effects of cadmium. Kankyo Hoken Report. 1989;56:1–345. (in Japanese with English abstract)Google Scholar
  16. 16.
    Aoshima K, Katoh T, Teranishi H, Horiguchi H, Kasuya M. Abnormalities of calcium, phosphorus and vitamin D metabolism with proximal renal tubular dysfunction in subjects environmentally exposed to cadmium. Jpn J Hyg. 1993;47:1009–20. (in Japanese with English abstract)CrossRefGoogle Scholar
  17. 17.
    Aoshima K. Recent advances in studies of itai-itai disease. Jpn J Toxicol Environ Health. 1997;43:317–30. (in Japanese with English abstract)CrossRefGoogle Scholar
  18. 18.
    World Health Organization (WHO). Environmental health criteria 134. cadmium. Geneva: WHO; 1992.Google Scholar
  19. 19.
    Ministry of Agriculture, Forestry and Fisheries of Japan. The status of cadmium concentrations in agricultural productions and intake of cadmium in Japan. http://www.maff.go.jp/j/syouan/nouan/kome/k_cd/jitai_sesyu/01_inv.html.
  20. 20.
    Ministry of Agriculture, Forestry and Fisheries of Japan. Food balance sheet. http://www.maff.go.jp/j/zyukyu/fbs/.
  21. 21.
    Ministry of Agriculture, Forestry and Fisheries of Japan. Surveys of actual status of cadmium concentrations in agricultural products. http://www.maff.go.jp/j/press/syouan/nouan/160223.html.
  22. 22.
    Ministry of Agriculture, Forestry and Fisheries of Japan. Monitoring of cadmium concentration of rice in rice-producing areas of Japan. http://www.maff.go.jp/j/syouan/nouan/kome/k_cd/documents/02_mon.html.
  23. 23.
    Food and Agriculture Organization. FAOSTAT. Food balance sheets. http://www.fao.org/faostat/en/#data/FBS
  24. 24.
    Moriguchi J, Ezaki T, Tsukahara T, Fukui Y, Ukai H, Okamoto S, Shimbo S, Sakurai H, Ikeda M. Effects of aging on cadmium and tubular dysfunction markers in urine from adult women in non-polluted areas. Int Arch Occup Environ Health. 2005;78:446–51.CrossRefGoogle Scholar
  25. 25.
    Ikeda M, Ohashi F, Fukui Y, Sakuragi S, Moriguchi J. Cadmium, chromium, lead, manganese and nickel concentrations in blood of women in non-polluted areas in Japan, as determined by inductively coupled plasma-sector field-mass spectrometry. Int Arch Occup Environ Health. 2011;84:139–50.CrossRefGoogle Scholar
  26. 26.
    Suwazono Y, Kobayashi E, Okubo Y, Nogawa K, Kido T, Nakagawa H. Renal effects of cadmium exposure in cadmium nonpolluted areas in Japan. Environ Res. 2000;84:44–55.CrossRefGoogle Scholar
  27. 27.
    Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, Kayama F. Dietary exposure to cadmium at close to the current provisional tolerable weekly intake does not affect renal function among female Japanese farmers. Environ Res. 2004;95:20–31.CrossRefGoogle Scholar
  28. 28.
    Horiguchi H, Aoshima K, Oguma E, Sasaki S, Miyamoto K, Hosoi Y, Katoh T, Kayama F. Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies. Int Arch Occup Environ Health. 2010;83:953–70.CrossRefGoogle Scholar
  29. 29.
    Sartor FA, Rondia DJ, Claeys FD, Staessen JA, Lauwerys RR, Bernard AM, Buchet JP, Roels HA, Bruaux PJ, Ducoffre GM, Lijnen PJ, Thijs LB, Amery AK. Impact of environmental cadmium pollution on cadmium exposure and body burden. Arch Environ Health. 1992;47:347–53.CrossRefGoogle Scholar
  30. 30.
    Sartor F, Rondia D, Claeys F, Buchet JP, Ducoffre G, Lauwerys R, Staessen J, Amery A. Factors influencing the cadmium body burden in a population study. IARC Sci Publ. 1992;118:101–6.Google Scholar
  31. 31.
    Suwazono Y, Sand S, Vahter M, Filipsson AF, Skerfving S, Lidfeldt J, Akesson A. Benchmark dose for cadmium-induced renal effects in humans. Environ Health Perspect. 2006;114:1072–6.CrossRefGoogle Scholar
  32. 32.
    Akesson A, Bjellerup P, Lundh T, Lidfeldt J, Nerbrand C, Samsioe G, Skerfving S, Vahter M. Cadmium-induced effects on bone in a population-based study of women. Environ Health Perspect. 2006;114:830–4.CrossRefGoogle Scholar
  33. 33.
    Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A. Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects. Environ Health Perspect. 2002;110:1185–90.CrossRefGoogle Scholar
  34. 34.
    Navas-Acien A, Tellez-Plaza M, Guallar E, Muntner P, Silbergeld E, Jaar B, Weaver V. Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis. Am J Epidemiol. 2009;170:1156–64.CrossRefGoogle Scholar
  35. 35.
    Grau-Perez M, Pichler G, Galan-Chilet I, Briongos-Figuero LS, Rentero-Garrido P, Lopez-Izquierdo R, Navas-Acien A, Weaver V, García-Barrera T, Gomez-Ariza JL, Martín-Escudero JC, Chaves FJ, Redon J, Tellez-Plaza M. Urine cadmium levels and albuminuria in a general population from Spain: A gene-environment interaction analysis. Environ Int. 2017;106:27–36.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Hagino HospitalToyamaJapan
  2. 2.Department of HygieneKitasato University School of MedicineSagamiharaJapan

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