Membrane Permeabilization Mechanisms
Many antimicrobial peptides are considered to kill microbes by permeabilizing cell membranes. This chapter summarizes the driving force of peptide binding to membranes; various mechanisms of lipid bilayer permeabilization including the barrel-stave, toroidal pore, and carpet models; and modes of permeabilization of bacterial and mammalian membranes.
KeywordsMembrane permeabilization Membrane binding Membrane curvature Barrel-stave model Toroidal pore model Carpet model
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