The Animal Model in ABO-Incompatible Organ Transplantation

  • Gang ChenEmail author
  • Song Chen


To better understand the mechanisms of such antibody-mediated rejection and explore novel strategies for clinical application, it is important to establish an animal research model of humoral rejection in ABO-incompatible organ transplantation. In this chapter, we will discuss the following issues: the ABO tissue groups and blood groups in nonhuman primates, natural anti-blood group antibody levels in sera of nonhuman primates, outcomes of ABO-incompatible organ transplantation in nonhuman primates, and establishment of humoral rejection models in ABO-incompatible organ transplantation in nonhuman primates.


Animal model Nonhuman primates Humoral rejection models 


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© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and TechnologyWuhanChina
  2. 2.Key Laboratory of Organ Transplantation, Ministry of Education/Ministry of Public HealthWuhanChina
  3. 3.Tongji Hospital, Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina

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