Critical Care Management of Guillain-Barré Syndrome

  • Ekaterina V. Bril
  • Konstantin A. Popugaev
  • Yuriy D. Udalov
  • Oleg V. Parinov
  • Maxim V. Zabelin
  • Alexandr S. Samoilov


Guillain-Barré syndrome (GBS), also called acute inflammatory demyelinating polyradiculoneuropathy (AIDP), is an inflammatory disorder affecting the peripheral nervous system that is characterized by acute or subacute onset and typically monophasic course of the disease. Some patients with this disorder need hospitalization in an intensive care unit (ICU). Among neuromuscular disorders, only several ones require monitoring and treatment at ICUs, namely, GBS, amyotrophic lateral sclerosis, and acute myasthenia gravis. Management of these patients in ICU normally includes specific therapy, vital signs’ monitoring, treatment of systemic complications, as well as the elimination of autonomic nervous system disorders.

GBS is considered the most common cause of inflammatory polyneuropathies, the annual frequency of which is estimated as 1–3 cases per 100,000 people.


Guillain-Barré Intensive care Intravenous immunoglobulins Plasma exchange Mechanical ventilation Tracheostomy 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Ekaterina V. Bril
    • 1
  • Konstantin A. Popugaev
    • 2
    • 3
  • Yuriy D. Udalov
    • 4
  • Oleg V. Parinov
    • 4
  • Maxim V. Zabelin
    • 4
  • Alexandr S. Samoilov
    • 4
  1. 1.Department of NeurologyBurnazian State Research Center, Federal and Biological Agency of RussiaMoscowRussia
  2. 2.Department of Anesthesia and Intensive CareBurnazian State Research Center, Federal and Biological Agency of RussiaMoscowRussia
  3. 3.Sklifosovsky Research Institute of Emergency MedicineMoscowRussia
  4. 4.Burnazian State Research Center of Federal and Biological Agency of RussiaMoscowRussia

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